EDF1 Activators
EDF1 activators are chemical compounds that enhance the function of EDF1, a protein involved in several cellular processes, including ER stress response and signal transduction of the EGFR and ERK pathways. Rapamycin, Torin 1, and AZD8055 are mTOR inhibitors that can enhance the interaction between EDF1 and mTOR, thus enhancing the function of EDF1. Thapsigargin, an inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), can lead to an increase in cytosolic calcium concentration, which can then lead to activation of PKC known to phosphorylate EDF1 and enhance its function. Tunicamycin and DTT, inhibitors of N-linked glycosylation and disruptors of disulfide bonds within proteins, respectively, can trigger ER stress and therefore enhance EDF1 function, as EDF1 is involved in ER stress responses.
Go 6983, a potent inhibitor of PKCs, can enhance the phosphorylation of EDF1, thereby enhancing its function. EGF, a known activator of the EGFR pathway, can enhance the function of EDF1 as EDF1is involved in the transduction of EGFR signals. Despite being an EGFR inhibitor, Gefitinib can enhance EDF1 function by inducing a stress response in the EGFR pathway, where EDF1 plays a significant role. Similarly, PD 98059 and U0126, both inhibitors of MEK in the ERK pathway, can also enhance the function of EDF1. They accomplish this by inducing a stress response in the ERK pathway, a pathway in which EDF1 is involved.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor. EDF1 is a known interactor of mTOR, and inhibition of mTOR by rapamycin can enhance the interaction between EDF1 and mTOR, thereby enhancing the function of EDF1. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
Torin 1 is a potent inhibitor of mTOR. Like Rapamycin, Torin 1 can enhance the interaction between EDF1 and mTOR, thus enhancing the function of EDF1. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
AZD8055 is a specific inhibitor of mTOR. It can enhance the function of EDF1 by enhancing the interaction between EDF1 and mTOR due to its inhibitory action on mTOR. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is an inhibitor of the sarcoplasmic/endoplasmic reticulum calcium ATPase (SERCA), leading to an increase in cytosolic calcium concentration. High cytosolic calcium levels can lead to activation of PKC, which is known to phosphorylate EDF1, thereby enhancing its function. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin is an inhibitor of N-linked glycosylation, which can lead to ER stress. EDF1 is known to be involved in ER stress responses, and thus, tunicamycin can enhance the function of EDF1 by triggering ER stress. | ||||||
Gö 6983 | 133053-19-7 | sc-203432 sc-203432A sc-203432B | 1 mg 5 mg 10 mg | $105.00 $299.00 $474.00 | 15 | |
Go 6983 is a broad-spectrum PKC inhibitor. Similar to staurosporine, Go 6983 can enhance the phosphorylation of EDF1, thereby enhancing its function. | ||||||
Gefitinib | 184475-35-2 | sc-202166 sc-202166A sc-202166B sc-202166C | 100 mg 250 mg 1 g 5 g | $63.00 $114.00 $218.00 $349.00 | 74 | |
Gefitinib is an EGFR inhibitor. Despite its inhibitory action, gefitinib can enhance EDF1 function by inducing a stress response in the EGFR pathway, in which EDF1 is involved. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is an inhibitor of MEK, a component of the ERK pathway. Despite its inhibitory action, PD 98059 can enhance EDF1 function by inducing a stress response in the ERK pathway, in which EDF1 is involved. | ||||||