EDF1 Inhibitors
Chemical inhibitors of EDF1 play a crucial role in modulating its function by targeting the calcium/calmodulin-dependent pathways that EDF1 is known to be involved with. Staurosporine, being a broad-spectrum kinase inhibitor, disrupts numerous kinase-dependent signaling cascades, including those that interact with calmodulin and its associated proteins. This disruption can lead to the functional inhibition of EDF1 by preventing the phosphorylation events necessary for its activity. KN-93 specifically inhibits Ca2+/calmodulin-dependent protein kinase II (CaMKII), which is a critical mediator of calcium signaling pathways. Since EDF1 is part of the calmodulin-dependent processes, the inhibition of CaMKII by KN-93 can prevent the subsequent steps in which EDF1 is involved, effectively inhibiting its function. Similarly, Trifluoperazine and W-7, as calmodulin antagonists, bind to calmodulin and inhibit its interaction with various proteins, including EDF1. This binding impedes EDF1's role in the signaling pathway and inhibits its function.
Other chemicals such as Calmidazolium and Phenothiazine also target calmodulin, restricting its regulatory actions and thereby inhibiting EDF1's function within the same pathway. Chlorpromazine and Thioridazine, by hindering calmodulin, block the downstream effects that would involve EDF1. Verapamil, a calcium channel blocker, indirectly affects calmodulin's activity by altering the intracellular concentration of calcium. This alteration is significant as calcium is a pivotal ion for calmodulin's binding and activation, and thus for EDF1's function within these pathways. Ophiobolin A, although non-specific, inhibits calmodulin-dependent processes by binding to calmodulin and preventing its activity, which includes the regulation of EDF1. Bepridil functions similarly by blocking calcium channels and inhibiting calmodulin-regulated pathways where EDF1 operates. Lastly, Compound 48/80 impedes mast cell degranulation, a calmodulin-dependent process, and thus can interfere with EDF1 function within this specific calmodulin-mediated signaling pathway.
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent kinase inhibitor that targets a wide range of kinases within cellular signaling pathways. EDF1 is known to be involved in calmodulin signaling, and by inhibiting kinases that interact with calmodulin, staurosporine can disrupt the signaling processes in which EDF1 participates, leading to the functional inhibition of EDF1. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a selective inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII). Since EDF1 is involved in Ca2+/calmodulin-dependent processes, KN-93 can inhibit the kinase activity of CaMKII, thereby hindering the pathway that relies on EDF1's function. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 is another calmodulin antagonist with the ability to inhibit calmodulin-regulated activities. By binding to calmodulin, W-7 prevents the interaction of calmodulin with its targets, which would include pathways utilizing EDF1, therefore functionally inhibiting EDF1. | ||||||
Calmidazolium chloride | 57265-65-3 | sc-201494 sc-201494A | 10 mg 50 mg | $153.00 $600.00 | 27 | |
Calmidazolium is a calmodulin inhibitor. It binds to calmodulin and inhibits its action, which includes modulation of enzymes and signaling molecules that are part of the calmodulin pathway, such as EDF1, thereby leading to its functional inhibition. | ||||||
Phenothiazine | 92-84-2 | sc-250686 sc-250686A | 50 g 250 g | $23.00 $43.00 | ||
Phenothiazine acts as a calmodulin pathway inhibitor. By inhibiting calmodulin, it disrupts pathways that EDF1 is a part of, functionally inhibiting EDF1’s role in these pathways. | ||||||
Chlorpromazine | 50-53-3 | sc-357313 sc-357313A | 5 g 25 g | $60.00 $108.00 | 21 | |
Chlorpromazine can bind to calmodulin and inhibit its function. Since EDF1 is involved in calmodulin-dependent pathways, the inhibition of calmodulin by chlorpromazine can lead to the functional inhibition of EDF1. | ||||||
Thioridazine Hydrochloride | 130-61-0 | sc-201149A sc-201149 sc-201149B sc-201149C sc-201149D | 5 mg 1 g 5 g 25 g 100 g | $20.00 $48.00 $102.00 $408.00 $1224.00 | ||
Thioridazine interferes with calmodulin activity. By blocking calmodulin, thioridazine can impair the function of EDF1 within the calmodulin-mediated signaling pathways. | ||||||
Verapamil | 52-53-9 | sc-507373 | 1 g | $367.00 | ||
Verapamil is a calcium channel blocker that can influence calmodulin activity by altering calcium influx. Through this mechanism, verapamil can indirectly inhibit the pathways that require calmodulin and EDF1, functionally inhibiting EDF1. | ||||||
Ophiobolin A | 4611-05-6 | sc-202266 sc-202266A sc-202266B | 100 µg 1 mg 5 mg | $43.00 $245.00 $714.00 | 7 | |
Ophiobolin A is a non-specific inhibitor of calmodulin-dependent processes. It can functionally inhibit EDF1 by binding to calmodulin and disrupting its interaction with target proteins such as EDF1 in signaling pathways. | ||||||
Bepridil | 64706-54-3 | sc-507400 | 100 mg | $1620.00 | ||
Bepridil is a calcium channel blocker with the ability to inhibit calmodulin-regulated enzymes and channels. This inhibition can lead to functional disruption of calmodulin-dependent pathways, including those involving EDF1. | ||||||