ECP Activators
ECP Activators are a diverse array of chemical compounds that indirectly enhance the functional activity of Eosinophil Cationic Protein (ECP) through modulation of various signaling pathways. Forskolin, by increasing intracellular cAMP levels, activates PKA, which can indirectly enhance the antimicrobial and immunoregulatory functions of ECP. Similarly, PMA, through the activation of PKC, may promote ECP's interaction with cellular targets, thereby augmenting its role in immune and inflammatory responses.Sphingosine-1-phosphate and Isoproterenol both act through signaling that involves cAMP and the PI3K/Akt pathway, which can contribute to the enhancement of ECP's immunomodulatory actions. The calcium ionophores Ionomycin and A23187 lead to an increase in intracellular calcium levels, activating calcium-dependent pathways that could indirectly enhance the activity of ECP, especially in its role in host defense mechanisms. The PI3K pathway inhibitor LY294002 may indirectly enhance ECP's activity by affecting the network of immune signaling in which ECP operates, while U0126 and SB203580, inhibitors of MEK and p38 MAPK respectively, may shift signaling dynamics in favor of ECP's functional pathways.
Anisomycin, which activates JNK, could modify MAPK pathway activity and therefore indirectly enhance ECP's functionality within inflammatory responses. EGCG and Curcumin both possess kinase inhibitory properties that can shift cellular signaling equilibria and, as a result, potentially enhance the activity of ECP in immune system modulation. These ECP activators work through their targeted effects on cellular signaling, facilitating the enhancement of ECP-mediated functions, such as antimicrobial activity and immunoregulation, without directly upregulating its expression or requiring direct activation of the protein itself.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which in turn activates PKA (protein kinase A). PKA can phosphorylate other proteins that may interact functionally with ECP, enhancing ECP's ability to mediate its known biological processes such as antimicrobial and immunomodulatory functions. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of Protein Kinase C (PKC). Activation of PKC has been implicated in the regulation of various proteins. PKC activation could enhance the functional activity of ECP by promoting its interaction with cellular targets in immune and inflammatory responses. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
D-erythro-Sphingosine-1-phosphate interacts with its receptors to activate intracellular signaling pathways, such as those mediated by PI3K/Akt. Activation of these pathways can lead to the functional enhancement of ECP, potentially increasing its role in immune signaling. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels leading to activation of PKA. PKA activation can enhance ECP's functionality indirectly, as PKA-mediated phosphorylation can affect proteins that modulate ECP's activity in immune responses. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels. Elevated calcium can activate signaling pathways that may indirectly enhance the functional activity of ECP, for example by modulating the immune response in which ECP is known to participate. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is also a calcium ionophore, which increases intracellular calcium and activates calcium-dependent signaling pathways. These pathways have the potential to indirectly enhance the activity of ECP, possibly by affecting the protein's role in cell signaling and host defense mechanisms. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that alters downstream signaling, potentially modifying the activity of proteins that interact with or regulate ECP. By influencing these pathways, LY294002 may indirectly enhance ECP's functional activity in the immune system. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 inhibits p38 MAPK, leading to changes in the cellular signaling environment. By inhibiting competitive pathways, SB203580 could potentially enhance the signaling pathways that lead to ECP activation, thus indirectly increasing ECP's functional activity. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator that could alter the activity of proteins within the MAPK pathway. By modulating this pathway, Anisomycin might enhance the functional activity of ECP by affecting cellular processes such as the inflammatory response in which ECP is implicated. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a known inhibitor of several kinases, and by inhibiting these, it can alter the balance of cellular signaling. This could indirectly enhance the activity of ECP by affecting the pathways that regulate or interact with ECP, particularly in immune function. | ||||||