ECH1 Activators
Enoyl-CoA hydratase 1 Activators as a chemical class, include various small molecules that can modulate the beta-oxidation of fatty acids. These activators do not interact with ECH1 directly but rather increase its activity by influencing the concentration of substrates, cofactors, or associated enzymes that participate in the same metabolic pathway. By altering the levels of Acetyl-CoA, NAD+, or Malonyl-CoA, or by impacting the transport and availability of fatty acids within mitochondria via L-Carnitine or the expression of genes related to beta-oxidation through PPAR-alpha agonists, these compounds can indirectly increase the demand for ECH1's enzymatic activity.
The mechanisms by which these activators operate are primarily through the modulation of metabolic flux or the regulation of gene expression that governs the beta-oxidation pathway. For instance, molecules like AMP can activate AMPK, which subsequently alters the levels of Malonyl-CoA by inhibiting acetyl-CoA carboxylase, resulting in an increased influx of fatty acids into the mitochondria for oxidation. Such alterations in the cellular metabolic environment necessitate an adaptive response in the activity of enzymes like ECH1, to maintain energy homeostasis. The specificity of this response is crucial to the cell's ability to adapt to changes in energy demand and availability, making the study of indirect activators within these pathways a vital aspect of understanding cellular metabolism.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $56.00 $186.00 $296.00 $655.00 $2550.00 $3500.00 $10500.00 | 4 | |
Nicotinamide adenine dinucleotide, in its oxidized form, is a crucial coenzyme in redox reactions. Although not a direct activator, the availability of NAD+ can modulate the beta-oxidation of fatty acids by accepting electrons in subsequent steps, which may indirectly necessitate an increase in ECH1 activity to maintain the balance of the cycle. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
L-Ascorbic acid, free acid (Vitamin C) can reduce oxidative stress, thereby maintaining the integrity of peroxisomes where ECH1 operates, indirectly enhancing the functional activity of ECH1 by preserving the cellular compartment it functions in. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $33.00 $77.00 $175.00 | 3 | |
L-Carnitine facilitates the transport of fatty acids into mitochondria. By promoting this transport, L-Carnitine can indirectly increase the availability of fatty acids for beta-oxidation, which may in turn enhance ECH1 activity due to increased substrate presence within the mitochondria. | ||||||
Adenosine phosphate(Vitamin B8) | 61-19-8 | sc-278678 sc-278678A | 50 g 100 g | $160.00 $240.00 | ||
Adenosine phosphate (Vitamin B8) can indirectly influence ECH1 activity by activating AMP-activated protein kinase (AMPK). AMPK can enhance fatty acid oxidation through the inhibition of acetyl-CoA carboxylase, which reduces Malonyl-CoA levels and thus potentially increases the activity of ECH1 indirectly. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
Alpha-lipoic acid acts as an antioxidant and is involved in mitochondrial bioenergetics. It can indirectly enhance ECH1 activity by maintaining mitochondrial health and thus supporting beta-oxidation processes. | ||||||
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $70.00 $180.00 | 1 | |
Coenzyme Q10 is involved in the electron transport chain and supports mitochondrial function. Enhanced mitochondrial efficiency can increase the demand for acyl-CoA products, which are generated by ECH1 activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $40.00 | 9 | |
PPAR-alpha agonists increase the expression of genes involved in fatty acid metabolism, potentially increasing the demand for ECH1's activity in beta-oxidation. | ||||||
Clofibrate | 637-07-0 | sc-200721 | 1 g | $32.00 | ||
Peroxisome proliferators such as Clofibrate can lead to an increase in the number of peroxisomes, thereby potentially enhancing the functional activity of ECH1 by increasing the cellular compartment in which it operates. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine activates AMPK, which enhances mitochondrial fatty acid oxidation. This upregulation may indirectly enhance the activity of ECH1 by increasing the utilization of its products. | ||||||
Acetyl-L-Carnitine | 3040-38-8 | sc-391881A sc-391881 | 250 mg 1 g | $140.00 $260.00 | 1 | |
Acetyl-L-carnitine enhances fatty acid oxidation in mitochondria, indirectly supporting ECH1 activity by increasing substrate flux through the beta-oxidation pathway. | ||||||