Molecular structure of Acetyl-L-Carnitine, CAS Number: 3040-38-8
Acetyl-L-Carnitine (CAS 3040-38-8)
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Alternate Names:
ALCAR; Acetylcarnitine
Application:
Acetyl-L-Carnitine is an acetylated form of L-carnitine.
CAS Number:
3040-38-8
Purity:
≥98%
Molecular Weight:
203.24
Molecular Formula:
C9H17NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Acetyl-L-Carnitine is an acetylated form of L-carnitine, a naturally occurring amino acid derivative often used in biochemical research for its role in mitochondrial function and metabolism. In the laboratory, it is recognized for its ability to donate acetyl groups, which can support energy metabolism and mitochondrial activity in various tissue types. This compound is also of interest in studies on neuronal plasticity and function, as it plays a role in the synthesis of the neurotransmitter acetylcholine. Research on Acetyl-L-Carnitine investigates its facilitation of fatty acid transport into mitochondria, where they undergo beta-oxidation for energy production. Additionally, it is used in investigations pertaining to muscle physiology and metabolism, where its effects on exercise performance and recovery are explored.
Acetyl-L-Carnitine (CAS 3040-38-8) References
- Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. | Pettegrew, JW., et al. 2000. Mol Psychiatry. 5: 616-32. PMID: 11126392
- Acetyl-l-carnitine induces muscarinic antinocieption in mice and rats. | Ghelardini, C., et al. 2002. Neuropharmacology. 43: 1180-7. PMID: 12504925
- Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism. | Rebouche, CJ. 2004. Ann N Y Acad Sci. 1033: 30-41. PMID: 15591001
- Acetyl-L-carnitine for the treatment of chemotherapy-induced peripheral neuropathy: a short review. | De Grandis, D. 2007. CNS Drugs. 21 Suppl 1: 39-43; discussion 45-6. PMID: 17696592
- Modulatory effect of acetyl-L-carnitine on amyloid precursor protein metabolism in hippocampal neurons. | Epis, R., et al. 2008. Eur J Pharmacol. 597: 51-6. PMID: 18801359
- Acetyl-L-carnitine increases artemin level and prevents neurotrophic factor alterations during neuropathy. | Vivoli, E., et al. 2010. Neuroscience. 167: 1168-74. PMID: 20302919
- Acetyl-L-Carnitine Modulates TP53 and IL10 Gene Expression Induced by 3-NPA Evoked Toxicity in PC12 Cells. | Virmani, A., et al. 2011. Curr Neuropharmacol. 9: 195-9. PMID: 21886589
- Upregulation of mGlu2 receptors via NF-κB p65 acetylation is involved in the Proneurogenic and antidepressant effects of acetyl-L-carnitine. | Cuccurazzu, B., et al. 2013. Neuropsychopharmacology. 38: 2220-30. PMID: 23670591
- Acetyl-L-carnitine: from a biological curiosity to a drug for the peripheral nervous system and beyond. | Onofrj, M., et al. 2013. Expert Rev Neurother. 13: 925-36. PMID: 23965166
- A review of current evidence for acetyl-l-carnitine in the treatment of depression. | Wang, SM., et al. 2014. J Psychiatr Res. 53: 30-7. PMID: 24607292
- Acetyl-L-carnitine in the treatment of peripheral neuropathic pain: a systematic review and meta-analysis of randomized controlled trials. | Li, S., et al. 2015. PLoS One. 10: e0119479. PMID: 25751285
- Acetyl-L-carnitine in chronic pain: A narrative review. | Sarzi-Puttini, P., et al. 2021. Pharmacol Res. 173: 105874. PMID: 34500063
- Acetyl-L-carnitine improves erectile function in bilateral cavernous nerve injury rats via promoting cavernous nerve regeneration. | Wang, J., et al. 2022. Andrology. 10: 984-996. PMID: 35420721
- Acetyl-L-carnitine attenuates Poly I:C-induced sickness behavior in mice. | Miura, S., et al. 2022. Biosci Biotechnol Biochem. 86: 1423-1430. PMID: 35945649
- Role of free L-carnitine and acetyl-L-carnitine in post-gonadal maturation of mammalian spermatozoa. | Jeulin, C. and Lewin, LM. 1996. Hum Reprod Update. 2: 87-102. PMID: 9079406
Activator of:
ATP5D, COX15, ECH1, MCAD, MRP-L42, MRP-L53, NDUFA2, NDUFA3, NDUFS2, OLIG1, PGK1, SHROOM4, Spatacsin, and TTC19.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Acetyl-L-Carnitine, 250 mg | sc-391881A | 250 mg | $143.00 | |||
Acetyl-L-Carnitine, 1 g | sc-391881 | 1 g | $265.00 |