EAT-2B Inhibitors
EAT-2B inhibitors are a class of chemical compounds that specifically target and modulate the activity of EAT-2B (EWS/FLI1-activated transcript 2B), an adaptor protein involved in the signaling pathways of immune cells. EAT-2B is part of the signaling lymphocytic activation molecule (SLAM) family, which is crucial in regulating immune responses, particularly within natural killer (NK) cells and certain T cells. EAT-2B acts as a signaling adaptor, interacting with other proteins in the SLAM-associated protein (SAP) family to modulate downstream signaling events that influence the activation, cytotoxicity, and cytokine production of these immune cells. By facilitating or inhibiting these interactions, EAT-2B plays a significant role in determining the strength and duration of immune responses, especially in contexts where precise control of immune activity is essential.
Inhibitors of EAT-2B function by disrupting the protein-protein interactions that EAT-2B mediates within immune cells. This can be achieved by binding directly to the EAT-2B protein or to its interaction partners, thereby blocking the formation of signaling complexes necessary for downstream signal transduction. Alternatively, these inhibitors might alter the conformation of EAT-2B or its binding sites, preventing effective signal transmission. By modulating EAT-2B activity, these inhibitors provide researchers with a tool to dissect the detailed mechanisms of immune cell signaling, particularly how adaptor proteins like EAT-2B contribute to the fine-tuning of immune responses. This allows for a deeper understanding of the molecular interactions that govern immune cell behavior, including how signals are integrated and translated into cellular actions, such as cytotoxicity or cytokine secretion. Such insights are crucial for understanding the broader regulatory networks that maintain immune balance and respond to various stimuli.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $47.00 $145.00 | 51 | |
Acts as a direct inhibitor by targeting multiple tyrosine kinases, including those involved in peptidyl-tyrosine phosphorylation. This directly inhibits Sh2d1b2's function in positive regulation of peptidyl-tyrosine phosphorylation and downstream signaling events. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
Inhibits Src kinase, impacting the regulation of natural killer cell-mediated cytotoxicity and positive regulation of peptidyl-tyrosine phosphorylation. This indirect inhibition influences Sh2d1b2 by modulating the upstream signaling pathways involved in its functions. | ||||||
Saracatinib | 379231-04-6 | sc-364607 sc-364607A | 10 mg 200 mg | $113.00 $1035.00 | 7 | |
Acts as a dual inhibitor of Src and Abl kinases, directly impacting peptidyl-tyrosine phosphorylation. This directly inhibits Sh2d1b2's function in positive regulation of peptidyl-tyrosine phosphorylation and downstream signaling events. | ||||||
WHI-P 154 | 211555-04-3 | sc-204395 sc-204395A | 10 mg 50 mg | $150.00 $630.00 | 3 | |
Inhibits Janus kinase 3 (JAK3), indirectly impacting Sh2d1b2's functions in peptidyl-tyrosine phosphorylation and positive regulation of these processes. This indirect inhibition modulates the signaling pathways upstream of Sh2d1b2, affecting its activity. | ||||||
PKC-412 | 120685-11-2 | sc-200691 sc-200691A | 1 mg 5 mg | $51.00 $112.00 | 10 | |
Acts as a multi-targeted kinase inhibitor, directly influencing peptidyl-tyrosine phosphorylation processes. This directly inhibits Sh2d1b2's function in positive regulation of peptidyl-tyrosine phosphorylation and downstream signaling events. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $246.00 $490.00 $536.00 | 16 | |
Inhibits JAK1 and JAK2, indirectly affecting Sh2d1b2's role in positive regulation of peptidyl-tyrosine phosphorylation. This indirect inhibition modulates the upstream signaling pathways involved in Sh2d1b2's functions. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
Acts as a tyrosine kinase inhibitor, directly impacting processes like peptidyl-tyrosine phosphorylation. This directly inhibits Sh2d1b2's function in positive regulation of peptidyl-tyrosine phosphorylation and downstream signaling events. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
Targets MEK1/2 within the MAPK/ERK pathway, indirectly inhibiting Sh2d1b2's functions in peptidyl-tyrosine phosphorylation and positive regulation of these processes. This indirect inhibition influences the gene by affecting downstream signaling events in these pathways. | ||||||
Sunitinib Malate | 341031-54-7 | sc-220177 sc-220177A sc-220177B | 10 mg 100 mg 3 g | $193.00 $510.00 $1072.00 | 4 | |
Acts as a multi-targeted receptor tyrosine kinase inhibitor, directly impacting peptidyl-tyrosine phosphorylation. This directly inhibits Sh2d1b2's function in positive regulation of peptidyl-tyrosine phosphorylation and downstream signaling events. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Inhibits JAK2, indirectly affecting Sh2d1b2's functions in peptidyl-tyrosine phosphorylation and positive regulation of these processes. This indirect inhibition modulates the upstream signaling pathways involved in Sh2d1b2's activities. | ||||||