E330016A19Rik Activators
E330016A19Rik Activators are a diverse array of chemical compounds that enhance the functional activity of E330016A19Rik through various signaling pathways. Forskolin and Isoproterenol, by increasing intracellular levels of cAMP, activate protein kinase A (PKA), which can directly or indirectly lead to the phosphorylation of E330016A19Rik, thereby enhancing its activity. The activation of PKC by Phorbol 12-myristate 13-acetate (PMA) may similarly induce phosphorylation events that could activate E330016A19Rik. Ionomycin and A23187 (Calcimycin) both serve as calcium ionophores, elevating intracellular calcium levels and potentially activating calcium-dependent protein kinases that might target E330016A19Rik. Furthermore, the kinase inhibitor Epigallocatechin gallate (EGCG) and the broad-spectrumprotein kinase inhibitor Staurosporine could modulate the cellular signaling landscape, indirectly enhancing signaling pathways that include E330016A19Rik.
In addition to these activators, compounds that specifically modulate lipid signaling and kinase pathways also contribute to the activation of E330016A19Rik. Sphingosine-1-phosphate, a bioactive lipid, activates its receptors and downstream signaling, which can include pathways involving E330016A19Rik. LY294002, a PI3K inhibitor, and U0126, a MEK inhibitor, both alter key signaling pathways; the former by modulating PI3K/Akt signaling and the latter by inhibiting the MAPK/ERK pathway, which may relieve negative regulation on pathways that activate E330016A19Rik. Thapsigargin, by increasing cytosolic calcium, can activate calcium-dependent kinases that might enhance the activity of E330016A19Rik. Diazoxide's opening of ATP-sensitive potassium channels has the potential to alter intracellular signaling cascades, providing another avenue for the activation of E330016A19Rik. Collectively, these compounds, through their targeted effects on specific cellular signaling pathways and processes, serve to enhance the functional activity of E330016A19Rik without directly increasing its expression levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC). PKC activation can lead to phosphorylation of target proteins and modulation of cellular signaling pathways, potentially involving the phosphorylation and activation of E330016A19Rik. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent protein kinases which may subsequently phosphorylate and activate E330016A19Rik. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a kinase inhibitor that by inhibiting certain kinases, may reduce competitive signaling pathways, thereby indirectly enhancing those involving E330016A19Rik activation. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate is a bioactive lipid that activates sphingosine-1-phosphate receptors and downstream signaling pathways, potentially leading to the activation of E330016A19Rik through G-protein coupled receptor signaling. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that modulates PI3K/Akt signaling. Inhibition of this pathway can shift the balance of cellular signaling, potentially relieving negative regulation on pathways that activate E330016A19Rik. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a MEK inhibitor that prevents the activation of MAPK/ERK pathway. This could lead to the alteration of signaling dynamics, potentially enhancing signaling pathways that involve the activation of E330016A19Rik. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin inhibits the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), leading to an increase in cytosolic calcium levels which may activate calcium-dependent signaling pathways involving E330016A19Rik activation. | ||||||
Diazoxide | 364-98-7 | sc-200980 | 1 g | $300.00 | 5 | |
Diazoxide opens ATP-sensitive potassium channels, hyperpolarizing the cell membrane. This can impact intracellular signaling cascades, potentially leading to the activation of signaling pathways involving E330016A19Rik. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases intracellular cAMP levels, potentially leading to the activation of cAMP-dependent pathways and subsequent phosphorylation of E330016A19Rik or associated proteins. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor, which might lead to selective activation of signaling pathways by inhibiting kinases that negatively regulate pathways involving E330016A19Rik. | ||||||