DUSP5 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
NSC 95397 | 93718-83-3 | sc-203654 sc-203654A | 10 mg 50 mg | $255.00 $847.00 | 9 | |
NSC-95397 acts as an inhibitor of DUSPs by binding to its active site. By doing so, it disrupts the enzyme′s ability to dephosphorylate its substrate proteins, including critical signaling molecules like ERK and JNK. This interference results in prolonged phosphorylation and activation of downstream signaling pathways. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits DUSPs by disrupting its dephosphorylation activity towards JNK and other substrates. This results in the prolonged activation of JNK and downstream signaling events that impact cellular functions, including cell proliferation and apoptosis. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 inhibits DUSPs indirectly by blocking p38 MAP kinase, a substrate of DUSPs. By doing so, it prevents p38 MAP kinase inactivation, leading to altered cellular responses mediated by p38 MAP kinase signaling. | ||||||
VX 745 | 209410-46-8 | sc-361401 sc-361401A | 10 mg 50 mg | $183.00 $842.00 | 4 | |
VX-745 is a small molecule inhibitor of DUSPs and JNK. It interferes with the dephosphorylation activity of DUSPs on JNK, leading to prolonged JNK activation and subsequent changes in cellular processes influenced by JNK signaling pathways. | ||||||
PD 198306 | 212631-61-3 | sc-203180 sc-203180A sc-203180B sc-203180C | 5 mg 50 mg 100 mg 500 mg | $245.00 $2000.00 $4000.00 $13500.00 | 3 | |
PD 198306 is a chemical inhibitor that specifically targets DUSPs. It disrupts DUSPs′s ability to dephosphorylate its substrates, including ERK and JNK. This leads to prolonged phosphorylation and activation of MAP kinases and downstream cellular responses. | ||||||