Drosophila, commonly known as fruit flies, have been a cornerstone in the study of genetics and developmental biology for over a century. One of the reasons for their extensive use in scientific research is the remarkable similarity between many of their genes and those in humans, allowing insights into human biology. Within the nervous system of Drosophila, axons are long projections of nerve cells (neurons) that transmit electrical and chemical signals. The growth, guidance, and branching of these axons are critical for establishing the intricate neural networks necessary for various functions. Drosophila axons, in particular, have been pivotal in understanding the molecular and cellular mechanisms underlying axonal development and function.
"Drosophila axons Inhibitors denote a class of compounds or molecules that can interfere with the normal function, development, or maintenance of axons in fruit flies. These inhibitors are powerful tools for researchers, allowing them to dissect the molecular pathways and cellular processes involved in axon biology. Some inhibitors might target proteins essential for axon guidance, ensuring that the axon grows in the correct direction. Others might interfere with molecules responsible for axon elongation or branching. Additionally, some inhibitors could affect the function of axonal transport, a process where cellular materials are shuttled to and from the neuron's cell body and its axon. By using these inhibitors, researchers can gain a deeper understanding of how disruptions in axonal processes can lead to neurodevelopmental or neurodegenerative conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine can inhibit microtubule polymerization, which is crucial for axonal transport and structure. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Like colchicine, nocodazole disrupts microtubule dynamics, affecting axon growth and guidance. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D inhibits actin polymerization, affecting axon growth cone dynamics. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers, preventing them from polymerizing, which affects axon growth cone movement. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A inhibits protein transport from the endoplasmic reticulum to the Golgi apparatus, potentially affecting axonal growth. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3 kinase inhibitor, which might influence growth cone dynamics and axon guidance. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another PI3 kinase inhibitor affecting growth cone dynamics. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 inhibits Rho kinase, which has a role in axon guidance by affecting the actin cytoskeleton. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A inhibits protein phosphatases, potentially affecting various signaling pathways in axon guidance. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a MAPK inhibitor, which can influence axonal growth and guidance pathways. | ||||||