DPP3 Inhibitors
Chemical inhibitors of DPP3 include a range of compounds that can indirectly influence the protein's activity by interacting with various biochemical pathways and cellular processes. Zinc Pyrithione, for example, targets metalloproteases by disrupting metal ion homeostasis, which is crucial for metalloproteins like DPP3. This disruption can inhibit the catalytic activity of DPP3 by altering the metal environment necessary for its function. Similarly, Ebselen, through its redox properties, can interact with thiol groups or essential metal ions at the active sites of enzymes. By doing so, it alters the enzyme activity, potentially leading to the inhibition of DPP3's function. Oltipraz can lead to increased cellular glutathione levels, which may interfere with the redox state of the cell and, consequently, the redox-dependent catalytic activity of DPP3. Disulfiram, known for its ability to chelate metal ions, can bind to DPP3's metal cofactors, thereby inhibiting its metalloenzyme activity.
The inhibition of kinase signaling pathways also plays a role in regulating DPP3 activity. PD 98059 and U0126 are inhibitors of MEK, which ultimately leads to reduced ERK phosphorylation. Since DPP3 activity can be regulated by phosphorylation, the inhibition of upstream kinases by these compounds can decrease DPP3 activation. LY294002, an inhibitor of PI3K, can alter cellular signaling that may lead to changes in DPP3 function. The inhibition of p38 MAP kinase by SB203580 can modify cellular responses to stress and inflammation, indirectly affecting DPP3 activity. Similarly, SP600125 inhibits JNK, which is involved in pathways regulating inflammation and apoptosis, processes that can modulate protease function and, in turn, affect DPP3 activity. Auranofin, by inhibiting thioredoxin reductase, changes the cellular redox state, which may lead to the inhibition of redox-sensitive enzymes like DPP3. Apocynin suppresses NADPH oxidase, thereby potentially reducing ROS levels and influencing the function of enzymes like DPP3 that are sensitive to redox changes. Lastly, NS-398, a COX-2 inhibitor, can alter prostaglandin levels, influencing various signaling pathways that regulate enzyme activity, including that of DPP3. Each of these compounds interacts with specific cellular components or pathways that are integral to the proper functioning of DPP3, leading to its inhibition.
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
Zinc Pyrithione can inhibit metalloproteases, which may indirectly inhibit DPP3 by disrupting metal ion homeostasis that is essential for the catalytic activity of metalloproteins, including DPP3. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen is a selenium-containing compound that can inhibit various enzyme activities through its redox properties. It can indirectly inhibit DPP3 by modifying thiol groups in active sites or interacting with essential metal ions, thus potentially disrupting the enzyme's function. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Oltipraz has been shown to modulate phase II detoxifying enzymes. It can indirectly inhibit DPP3 by inducing an increase in cellular glutathione levels, which may interfere with the redox state of the cell, thus affecting the catalytic activity of DPP3 that relies on specific redox conditions. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can inhibit aldehyde dehydrogenase and other metalloenzymes. It can indirectly inhibit DPP3 by binding to metal ions that are cofactors for metalloenzymes, thereby potentially disrupting the metal-dependent enzyme activity of DPP3. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a selective inhibitor of MEK, which in turn inhibits ERK phosphorylation. DPP3 can be regulated by phosphorylation; therefore, by inhibiting upstream kinases, PD 98059 may indirectly reduce the phosphorylation and subsequent activation of DPP3. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, this compound can change cellular signaling and indirectly lead to the inhibition of DPP3 function, as PI3K influences various intracellular processes including those related to protease function. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a p38 MAP kinase inhibitor. Inhibition of p38 MAP kinase can alter cellular responses to stress and inflammation, which may indirectly affect DPP3 activity by changing the protease activation state within the cell. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK). By inhibiting JNK, this compound can influence the signaling pathways that regulate inflammatory responses and apoptosis, possibly leading to an indirect inhibition of DPP3 activity, as these cellular processes can modulate protease function. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $150.00 $210.00 $1899.00 | 39 | |
Auranofin is a gold-containing compound known to inhibit thioredoxin reductase. By inhibiting this enzyme, auranofin can alter the cellular redox environment, which may indirectly inhibit DPP3 by affecting the redox-sensitive aspects of its catalytic mechanism. | ||||||
Apocynin | 498-02-2 | sc-203321 sc-203321A sc-203321B sc-203321C | 1 g 10 g 100 g 500 g | $26.00 $67.00 $114.00 $353.00 | 74 | |
Apocynin inhibits NADPH oxidase, potentially reducing the production of reactive oxygen species (ROS). Reduced ROS levels can alter the redox state of the cell and indirectly affect the function of redox-sensitive enzymes like DPP3. | ||||||