Date published: 2026-4-1

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DNAS1L3 Inhibitors

DNAS1L3 inhibitors are a class of chemical compounds meticulously designed to effectively obstruct the enzymatic activity of DNAS1L3, a member of the DNA methyltransferase family. These inhibitors are meticulously crafted to interact with specific domains or key regions within the DNAS1L3 enzyme's structure, thereby eliciting a precise interference with its intrinsic catalytic function. The primary objective of these inhibitors is to impede the enzymatic transfer of methyl groups to cytosine residues that are intrinsic to DNA molecules. By intricately disrupting this fundamental biochemical process, DNAS1L3 inhibitors intricately manipulate the intricate landscape of DNA methylation patterns. DNA methylation holds paramount significance as a key epigenetic mechanism orchestrating gene expression regulation and cellular development. The selective and precise targeting of DNAS1L3 by these inhibitors precipitates a cascade of changes in DNA methylation patterns, subsequently modulating the functional dynamics of genes and genetic pathways.

In the realm of scientific research, DNAS1L3 inhibitors emerge as indispensable tools for advancing our understanding of the intricate mechanisms that underpin epigenetic regulation. Their meticulously tailored interactions with DNAS1L3 enzyme afford researchers a vantage point from which to scrutinize the pivotal role of DNA methylation in gene expression modulation. The insights gleaned from such investigations transcend the confines of individual genes, offering a broader comprehension of cellular processes, developmental trajectories, and potential implications in diverse biological contexts. By engaging with DNAS1L3 at a molecular level, these inhibitors illuminate the delicate interplay between epigenetic modifications and gene regulation. As such, they enable researchers to delve into the intricate mechanisms that govern cellular identity, response to environmental cues, and myriad other phenomena. Consequently, the class of DNAS1L3 inhibitors stands as a cornerstone in the edifice of epigenetics, unraveling the intricate threads that weave the tapestry of biological complexity and providing a profound avenue for scientific exploration and discovery.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

5-Azacytidine

320-67-2sc-221003
500 mg
$280.00
4
(1)

Incorporates into DNA, traps DNMT1, leading to its degradation, and causes hypomethylation.

5-Aza-2′-Deoxycytidine

2353-33-5sc-202424
sc-202424A
sc-202424B
25 mg
100 mg
250 mg
$218.00
$322.00
$426.00
7
(1)

Gets incorporated into DNA, covalently binds DNMT1, causing DNA demethylation and gene reactivation.

RG 108

48208-26-0sc-204235
sc-204235A
10 mg
50 mg
$131.00
$515.00
2
(1)

Binds to the active site of DNMT1, inhibiting its enzymatic activity and inducing DNA hypomethylation.

SGI-1027

1020149-73-8sc-473875
10 mg
$213.00
(0)

Acts as a non-nucleoside inhibitor of DNMT1, causing hypomethylation by disrupting DNMT1 function.

Zebularine

3690-10-6sc-203315
sc-203315A
sc-203315B
10 mg
25 mg
100 mg
$129.00
$284.00
$1004.00
3
(1)

Gets incorporated into DNA, traps DNMT1, and leads to DNA hypomethylation, activating silenced genes.

Hydralazine-15N4 Hydrochloride

304-20-1 (unlabeled)sc-490605
1 mg
$480.00
(0)

Allosterically inhibits DNMT1 by disrupting its binding to DNA, causing DNA hypomethylation and gene reactivation.

Psammaplin A

110659-91-1sc-258049
sc-258049A
1 mg
5 mg
$90.00
$422.00
7
(1)

Inhibits DNMT1 enzymatic activity through direct binding to the enzyme, resulting in reduced DNA methylation.