Date published: 2025-10-23

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DIO Antibodies

Santa Cruz Biotechnology features a diverse variety of DIO Antibodies for targeting deiodinase iodothyronine type II (DIO2) protein. DIO Antibodies are compatible with western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). DIO2 plays a critical role in thyroid hormone metabolism by converting the prohormone thyroxine (T4) into the active form, triiodothyronine (T3), which is essential for regulating metabolism, growth, and development. Understanding DIO2 function is crucial for elucidating the mechanisms underlying thyroid-related disorders and metabolic diseases. The study of DIO2 and its regulation can provide insights into therapeutic targets for conditions such as hypothyroidism and obesity. Research focused on DIO2 continues to reveal new connections between thyroid hormone signaling and various physiological processes. Investigating DIO2 expression patterns helps scientists better understand tissue-specific responses to thyroid hormones. Exploring DIO2 activity provides valuable information about metabolic regulation across different organ systems. Santa Cruz Biotechnology monoclonal antibodies support researchers worldwide in advancing our understanding of thyroid hormone biology and its impact on human health.

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DIO Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

DIO1 Antibody (B-7)

sc-515198mouse IgG2b κ78-99 (m)WB, IP, IF, ELISAm, r, h
3
(2)

DIO CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

DIO1 CRISPR/Cas9 KO Plasmid (h)

sc-405162hGene KnockoutGFP0
(0)

DIO1 HDR Plasmid (h)

sc-405162-HDRhHomology Directed RepairPuromycin0
(0)

DIO1 Double Nickase Plasmid (h)

sc-405162-NIChGene KnockoutPuromycin0
(0)

DIO1 Double Nickase Plasmid (h2)

sc-405162-NIC-2hGene KnockoutPuromycin0
(0)

DIO1 CRISPR/Cas9 KO Plasmid (m)

sc-420002mGene KnockoutGFP0
(0)

DIO1 Double Nickase Plasmid (m)

sc-420002-NICmGene KnockoutPuromycin0
(0)

DIO1 Double Nickase Plasmid (m2)

sc-420002-NIC-2mGene KnockoutPuromycin0
(0)

DIO2 CRISPR/Cas9 KO Plasmid (h)

sc-402262hGene KnockoutGFP
3
(0)

DIO2 HDR Plasmid (h)

sc-402262-HDRhHomology Directed RepairPuromycin
3
(0)

DIO2 Double Nickase Plasmid (h)

sc-402262-NIChGene KnockoutPuromycin
3
(0)

DIO2 Double Nickase Plasmid (h2)

sc-402262-NIC-2hGene KnockoutPuromycin
3
(0)

DIO2 CRISPR/Cas9 KO Plasmid (m)

sc-420003mGene KnockoutGFP
2
(0)

DIO2 HDR Plasmid (m)

sc-420003-HDRmHomology Directed RepairPuromycin
2
(0)

DIO2 Double Nickase Plasmid (m)

sc-420003-NICmGene KnockoutPuromycin
2
(0)

DIO2 Double Nickase Plasmid (m2)

sc-420003-NIC-2mGene KnockoutPuromycin
2
(0)

DIO3 CRISPR/Cas9 KO Plasmid (h)

sc-403729hGene KnockoutGFP0
(0)

DIO3 HDR Plasmid (h)

sc-403729-HDRhHomology Directed RepairPuromycin0
(0)

DIO3 Double Nickase Plasmid (h)

sc-403729-NIChGene KnockoutPuromycin0
(0)

DIO3 Double Nickase Plasmid (h2)

sc-403729-NIC-2hGene KnockoutPuromycin0
(0)

DIO3 CRISPR/Cas9 KO Plasmid (m)

sc-430733mGene KnockoutGFP
2
(0)

DIO3 HDR Plasmid (m)

sc-430733-HDRmHomology Directed RepairPuromycin
2
(0)

DIO3 Double Nickase Plasmid (m)

sc-430733-NICmGene KnockoutPuromycin
2
(0)

DIO3 Double Nickase Plasmid (m2)

sc-430733-NIC-2mGene KnockoutPuromycin
2
(0)

DIO CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

DIO1 CRISPR Activation Plasmid (h)

sc-405162-ACThGene ActivationPuro, Blast, Hygro0
(0)

DIO1 CRISPR Activation Plasmid (h2)

sc-405162-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

DIO1 Lentiviral Activation Particles (h)

sc-405162-LAChGene ActivationPuro, Blast, Hygro0
(0)

DIO1 Lentiviral Activation Particles (h2)

sc-405162-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

DIO1 CRISPR Activation Plasmid (m)

sc-420002-ACTmGene ActivationPuro, Blast, Hygro0
(0)

DIO1 CRISPR Activation Plasmid (m2)

sc-420002-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

DIO1 Lentiviral Activation Particles (m)

sc-420002-LACmGene ActivationPuro, Blast, Hygro0
(0)

DIO1 Lentiviral Activation Particles (m2)

sc-420002-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

DIO2 CRISPR Activation Plasmid (h)

sc-402262-ACThGene ActivationPuro, Blast, Hygro
3
(0)

DIO2 CRISPR Activation Plasmid (h2)

sc-402262-ACT-2hGene ActivationPuro, Blast, Hygro
3
(0)

DIO2 Lentiviral Activation Particles (h)

sc-402262-LAChGene ActivationPuro, Blast, Hygro
3
(0)

DIO2 Lentiviral Activation Particles (h2)

sc-402262-LAC-2hGene ActivationPuro, Blast, Hygro
3
(0)

DIO2 CRISPR Activation Plasmid (m)

sc-420003-ACTmGene ActivationPuro, Blast, Hygro
2
(0)

DIO2 CRISPR Activation Plasmid (m2)

sc-420003-ACT-2mGene ActivationPuro, Blast, Hygro
2
(0)

DIO2 Lentiviral Activation Particles (m)

sc-420003-LACmGene ActivationPuro, Blast, Hygro
2
(0)

DIO2 Lentiviral Activation Particles (m2)

sc-420003-LAC-2mGene ActivationPuro, Blast, Hygro
2
(0)

DIO3 CRISPR Activation Plasmid (h)

sc-403729-ACThGene ActivationPuro, Blast, Hygro0
(0)

DIO3 CRISPR Activation Plasmid (h2)

sc-403729-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

DIO3 Lentiviral Activation Particles (h)

sc-403729-LAChGene ActivationPuro, Blast, Hygro0
(0)

DIO3 Lentiviral Activation Particles (h2)

sc-403729-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

DIO3 CRISPR Activation Plasmid (m)

sc-430733-ACTmGene ActivationPuro, Blast, Hygro
2
(0)

DIO3 CRISPR Activation Plasmid (m2)

sc-430733-ACT-2mGene ActivationPuro, Blast, Hygro
2
(0)

DIO3 Lentiviral Activation Particles (m)

sc-430733-LACmGene ActivationPuro, Blast, Hygro
2
(0)

DIO3 Lentiviral Activation Particles (m2)

sc-430733-LAC-2mGene ActivationPuro, Blast, Hygro
2
(0)

DIO siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

DIO1 siRNA (h)

sc-77146hGene SilencingN/A
1
(0)

DIO1 shRNA Plasmid (h)

sc-77146-SHhGene SilencingPuromycin
1
(0)

DIO1 shRNA (h) Lentiviral Particles

sc-77146-VhGene SilencingPuromycin
1
(0)

DIO1 siRNA (m)

sc-77147mGene SilencingN/A0
(0)

DIO1 shRNA Plasmid (m)

sc-77147-SHmGene SilencingPuromycin0
(0)

DIO1 shRNA (m) Lentiviral Particles

sc-77147-VmGene SilencingPuromycin0
(0)

DIO2 siRNA (h)

sc-77148hGene SilencingN/A0
(0)

DIO2 shRNA Plasmid (h)

sc-77148-SHhGene SilencingPuromycin0
(0)

DIO2 shRNA (h) Lentiviral Particles

sc-77148-VhGene SilencingPuromycin0
(0)

DIO2 siRNA (m)

sc-77149mGene SilencingN/A0
(0)

DIO2 shRNA Plasmid (m)

sc-77149-SHmGene SilencingPuromycin0
(0)

DIO2 shRNA (m) Lentiviral Particles

sc-77149-VmGene SilencingPuromycin0
(0)

DIO3 siRNA (h)

sc-77150hGene SilencingN/A
2
(0)

DIO3 shRNA Plasmid (h)

sc-77150-SHhGene SilencingPuromycin
2
(0)

DIO3 shRNA (h) Lentiviral Particles

sc-77150-VhGene SilencingPuromycin
2
(0)

DIO3 siRNA (m)

sc-77151mGene SilencingN/A0
(0)

DIO3 shRNA Plasmid (m)

sc-77151-SHmGene SilencingPuromycin0
(0)

DIO3 shRNA (m) Lentiviral Particles

sc-77151-VmGene SilencingPuromycin0
(0)