DHRS11 Inhibitors
DHRS11 inhibitors such as agents like methotrexate and disulfiram may influence the availability of essential cofactors or disrupt the cellular redox state, which is vital for the proper function of many dehydrogenases, including DHRS11. Compounds such as 3-bromopyruvate and Vitamin K3 can change the metabolic and oxidative state of cells, which in turn may impact the activity of DHRS11, particularly if the enzyme's function is tied to cellular redox reactions. Allopurinol and diphenyleneiodonium target specific aspects of cellular metabolism and redox control, potentially affecting the enzymatic cascades that DHRS11 is part of.
Mitochondrial inhibitors like rotenone and sodium azide may cause broader changes in the cellular redox environment, which might affect the function of redox-sensitive enzymes like DHRS11. Additionally, modulators of cellular stress responses, such as 17-AAG, can affect protein stability and expression, potentially impacting the levels of DHRS11 within the cell. Zileuton and fenofibrate indicate how alteration in lipid signaling pathways may indirectly affect proteins involved in lipid metabolism or related pathways, which could include DHRS11 if it has a role in these processes.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Inhibits dihydrofolate reductase, which could lead to depletion of cofactors necessary for DHRS11 activity. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $53.00 $89.00 | 7 | |
Binds to copper and can inhibit aldehyde dehydrogenases, potentially affecting cofactor availability for DHRS11. | ||||||
Vitamin K3 | 58-27-5 | sc-205990B sc-205990 sc-205990A sc-205990C sc-205990D | 5 g 10 g 25 g 100 g 500 g | $26.00 $36.00 $47.00 $136.00 $455.00 | 3 | |
A quinone that can affect redox cycling and oxidative stress, potentially altering the redox state required for DHRS11 activity. | ||||||
Allopurinol | 315-30-0 | sc-207272 | 25 g | $131.00 | ||
Inhibitor of xanthine oxidase, may influence oxidative stress pathways and thereby affect DHRS11 activity. | ||||||
Diphenyleneiodonium chloride | 4673-26-1 | sc-202584E sc-202584 sc-202584D sc-202584A sc-202584B sc-202584C | 10 mg 25 mg 50 mg 100 mg 250 mg 500 mg | $151.00 $136.00 $317.00 $405.00 $944.00 $1837.00 | 24 | |
Inhibits flavoproteins and could affect the redox state, potentially altering the function of DHRS11. | ||||||
Rotenone | 83-79-4 | sc-203242 sc-203242A | 1 g 5 g | $89.00 $259.00 | 41 | |
Inhibits mitochondrial complex I and could change the cellular redox environment, impacting DHRS11 activity. | ||||||
Sodium azide | 26628-22-8 | sc-208393 sc-208393B sc-208393C sc-208393D sc-208393A | 25 g 250 g 1 kg 2.5 kg 100 g | $43.00 $155.00 $393.00 $862.00 $90.00 | 8 | |
Inhibits cytochrome c oxidase in mitochondria, potentially affecting the redox balance and DHRS11 activity. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Proton pump inhibitor that may alter cellular pH levels, potentially impacting DHRS11's enzymatic activity. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
Hsp90 inhibitor that may destabilize client proteins, potentially affecting the stability of DHRS11. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $84.00 $307.00 $369.00 $1254.00 | 8 | |
5-lipoxygenase inhibitor that may alter lipid signaling pathways, potentially impacting DHRS11's role in these pathways. | ||||||