DHRS11 Inhibitors

DHRS11 inhibitors such as agents like methotrexate and disulfiram may influence the availability of essential cofactors or disrupt the cellular redox state, which is vital for the proper function of many dehydrogenases, including DHRS11. Compounds such as 3-bromopyruvate and Vitamin K3 can change the metabolic and oxidative state of cells, which in turn may impact the activity of DHRS11, particularly if the enzyme's function is tied to cellular redox reactions. Allopurinol and diphenyleneiodonium target specific aspects of cellular metabolism and redox control, potentially affecting the enzymatic cascades that DHRS11 is part of.

Mitochondrial inhibitors like rotenone and sodium azide may cause broader changes in the cellular redox environment, which might affect the function of redox-sensitive enzymes like DHRS11. Additionally, modulators of cellular stress responses, such as 17-AAG, can affect protein stability and expression, potentially impacting the levels of DHRS11 within the cell. Zileuton and fenofibrate indicate how alteration in lipid signaling pathways may indirectly affect proteins involved in lipid metabolism or related pathways, which could include DHRS11 if it has a role in these processes.