dHAND Activators
The identified chemicals as dHAND activators provide insights into the signaling pathways that contribute to the activation of dHAND during cardiac development. Forskolin, Dibutyryl cAMP, Isoproterenol, Epinephrine, Prostaglandin E1 (PGE1), Norepinephrine, Iloprost, Terbutaline, Salbutamol, Cilostazol, Milrinone, and BRL 37344 collectively showcase the importance of cAMP-mediated signaling in promoting dHAND activation. Forskolin, a direct stimulator of adenylyl cyclase, initiates a cascade leading to increased cAMP levels. This activates PKA, which modulates downstream effectors, ultimately influencing the expression and function of dHAND. Similarly, Dibutyryl cAMP, as a cell-permeable analog of cAMP, directly increases intracellular cAMP levels, promoting dHAND activation by bypassing adenylyl cyclase activation.
Isoproterenol, Epinephrine, Prostaglandin E1 (PGE1), Norepinephrine, Iloprost, Terbutaline, Salbutamol, Cilostazol, Milrinone, and BRL 37344, all acting through β-adrenergic receptors or phosphodiesterase inhibition, increase cAMP levels, leading to PKA activation and subsequent modulation of dHAND. This emphasizes the role of sympathetic signaling and phosphodiesterase activity in the activation of dHAND during cardiac development. The collective action of these chemicals provides a comprehensive view of the cAMP-mediated signaling pathways that play a crucial role in promoting dHAND activation. Understanding these mechanisms is essential for unraveling the complexities of cardiac development, offering avenues for research in heart defects and related pathologies.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates dHAND by directly stimulating adenylyl cyclase, leading to increased cAMP levels. Elevated cAMP levels activate protein kinase A (PKA), which, in turn, phosphorylates downstream effectors, modulating the expression and function of dHAND. This highlights the role of cAMP/PKA signaling in promoting dHAND activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl cAMP activates dHAND by directly increasing intracellular cAMP levels. Acting as a cell-permeable analog of cAMP, dibutyryl cAMP bypasses the need for adenylyl cyclase activation, leading to the activation of PKA and downstream effectors that modulate dHAND expression and function. This underscores the importance of cAMP-mediated signaling in promoting dHAND activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol activates dHAND by binding to β-adrenergic receptors, leading to increased cAMP production. The subsequent activation of PKA, driven by elevated cAMP levels, modulates downstream effectors, ultimately influencing the expression and function of dHAND. This reveals the connection between β-adrenergic signaling and the activation of dHAND, emphasizing the role of sympathetic signaling in cardiac development. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine activates dHAND by binding to β-adrenergic receptors, initiating a signaling cascade that increases cAMP production. Elevated cAMP levels activate PKA, which, in turn, modulates downstream effectors, influencing the expression and function of dHAND. This highlights the involvement of sympathetic signaling in the activation of dHAND during cardiac development. | ||||||
PGE1 (Prostaglandin E1) | 745-65-3 | sc-201223 sc-201223A | 1 mg 10 mg | $30.00 $142.00 | 16 | |
Prostaglandin E1 (PGE1) activates dHAND by directly increasing intracellular cAMP levels. Through its action on adenylate cyclase, PGE1 stimulates cAMP production, activating PKA and downstream effectors that modulate dHAND expression and function. This emphasizes the role of prostaglandin-mediated signaling in promoting dHAND activation. | ||||||
L-Noradrenaline | 51-41-2 | sc-357366 sc-357366A | 1 g 5 g | $320.00 $475.00 | 3 | |
Norepinephrine activates dHAND by binding to β-adrenergic receptors, initiating a signaling cascade that increases cAMP production. The subsequent activation of PKA, driven by elevated cAMP levels, modulates downstream effectors, ultimately influencing the expression and function of dHAND. This underscores the involvement of sympathetic signaling in the activation of dHAND during cardiac development. | ||||||
Iloprost | 78919-13-8 | sc-205349 sc-205349A | 500 µg 1 mg | $155.00 $269.00 | ||
Iloprost activates dHAND by directly increasing intracellular cAMP levels. Through its action on adenylate cyclase, Iloprost stimulates cAMP production, activating PKA and downstream effectors that modulate dHAND expression and function. This highlights the role of prostacyclin-mediated signaling in promoting dHAND activation. | ||||||
Salbutamol | 18559-94-9 | sc-253527 sc-253527A | 25 mg 50 mg | $92.00 $138.00 | ||
Salbutamol activates dHAND by binding to β-adrenergic receptors, initiating a signaling cascade that increases cAMP production. Elevated cAMP levels activate PKA, which modulates downstream effectors, ultimately influencing the expression and function of dHAND. This emphasizes the role of sympathetic signaling in the activation of dHAND during cardiac development. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol activates dHAND by directly increasing intracellular cAMP levels. Through its action on phosphodiesterase III, Cilostazol inhibits cAMP degradation, leading to elevated cAMP levels. The subsequent activation of PKA modulates downstream effectors, influencing the expression and function of dHAND. This underscores the potential of phosphodiesterase inhibitors in promoting dHAND activation through cAMP-mediated signaling. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone activates dHAND by directly increasing intracellular cAMP levels. Acting as a phosphodiesterase III inhibitor, Milrinone prevents cAMP degradation, leading to elevated cAMP levels. The subsequent activation of PKA modulates downstream effectors, influencing the expression and function of dHAND. This highlights the potential of phosphodiesterase inhibitors in promoting dHAND activation through cAMP-mediated signaling. | ||||||