DFNB59 Inhibitors

DFNB59 inhibitors, as described, primarily focus on modulating pathways associated with pejvakin or its associated inner ear homeostasis. Several compounds in this category, including Ouabain, Furosemide, and Ethacrynic acid, are involved in the regulation of ion balance in the inner ear, a key process that Pjvk is believed to have a role in. By modulating ion balance, these compounds can influence the mechanotransduction process and the function of Pjvk.

Other compounds, such as Gentamicin, Neomycin, and Cisplatin, are known ototoxic agents that can induce auditory toxicity. While the exact mechanisms of their ototoxic effects are multifaceted, their influence on the inner ear suggests interactions with Pjvk-associated pathways. Similarly, drugs like Salicylate, known to induce reversible hearing loss, and other compounds like D-methionine, which provide protection against ototoxicity, may hold indirect influence over Pjvk function. Lastly, chemicals such as Acetaminophen in overdose conditions, Toluene, and Quinine have demonstrated auditory effects, pointing towards their possible involvement in pathways or processes associated with Pjvk.