DEPDC6 Inhibitors
Inhibitors of DEPDC6 function through diverse mechanisms to dampen its role in cellular signaling, particularly within the mTORC1 complex. Certain compounds achieve this by directly targeting mTORC1, forming complexes with proteins that bind mTOR, thus obstructing DEPDC6's essential contributions to mTORC1 kinase activity. Others function upstream, inhibiting enzymes like PI3K, which are pivotal for the activation of mTORC1; this in turn indirectly weakens DEPDC6's influence on mTORC1-mediated processes. Some inhibitors work by altering cellular energy homeostasis, for instance, by inhibiting key enzymes in fatty acid metabolism, subsequently leading to a decrease in mTORC1 signaling and the consequent reduction of DEPDC6 activity.
Furthermore, certain compounds activate AMPK, a cellular energy sensor that negatively regulates mTORC1 signaling, thereby attenuating DEPDC6's involvement in growth and proliferation pathways. This can be achieved either through direct activation of AMPK or via modulation of pathways influencing AMPK activity, resulting in a diminished functional presence of DEPDC6 in mTORC1 signaling. Additionally, ATP-competitive inhibitors that target both mTORC1 and mTORC2 complexes further inhibit the participation of DEPDC6 in these pathways. Other compounds, through the activation of proteins involved in deacetylation processes, can similarly leadto a reduction in mTORC1 activity and hence a decline in DEPDC6's role.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that directly binds to FKBP12 creating a complex that inhibits mTORC1, to which DEPDC6 is a component. Inhibition of mTORC1 leads to reduced DEPDC6 activity as part of the complex. | ||||||
Torin 1 | 1222998-36-8 | sc-396760 | 10 mg | $245.00 | 7 | |
A selective ATP-competitive mTOR inhibitor that targets both mTORC1 and mTORC2 complexes, leading to decreased DEPDC6 activity by disrupting its association within these complexes. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
An ATP-competitive inhibitor of mTOR kinase that inhibits both mTORC1 and mTORC2, thereby decreasing DEPDC6 activity by impairing the assembly and function of these complexes. | ||||||
WYE-354 | 1062169-56-5 | sc-364652 sc-364652A | 10 mg 50 mg | $286.00 $1200.00 | ||
Targets mTOR and inhibits its kinase activity, resulting in diminished mTORC1 and mTORC2 signaling and consequently reducing DEPDC6 function within these complexes. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $163.00 $352.00 | 12 | |
A potent ATP-competitive inhibitor of mTOR kinase affecting both mTORC1 and mTORC2, leading to a downregulation of DEPDC6 activity due to disruption of these complexes. | ||||||
INK 128 | 1224844-38-5 | sc-364511 sc-364511A | 5 mg 50 mg | $321.00 $1835.00 | ||
A selective ATP-competitive mTOR inhibitor that impairs mTORC1 and mTORC2, leading to reduced signaling and decreased activity of DEPDC6 as part of these complexes. | ||||||
Palomid 529 | 914913-88-5 | sc-364563 sc-364563A | 10 mg 50 mg | $300.00 $1000.00 | ||
A dual PI3K/Akt/mTOR inhibitor that disrupts the activation and signaling of mTORC1 and mTORC2, indirectly leading to a reduction in DEPDC6 activity within these pathways. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
An ATP-competitive mTOR inhibitor that specifically reduces mTORC1 and mTORC2 signaling, thereby decreasing the activity of DEPDC6 involved in these complexes. | ||||||
OSI-027 | 936890-98-1 | sc-364557 sc-364557A | 10 mg 50 mg | $437.00 $1186.00 | 1 | |
An ATP-competitive inhibitor of mTOR that selectively inhibits both mTORC1 and mTORC2, leading to reduced DEPDC6 activity as it disrupts the function of these complexes. | ||||||
Everolimus | 159351-69-6 | sc-218452 sc-218452A | 5 mg 50 mg | $131.00 $651.00 | 7 | |
An mTOR inhibitor that forms a complex with FKBP12, similar to Rapamycin, inhibiting mTORC1 signaling and thereby decreasing the activity of DEPDC6 in this complex. | ||||||