DDTL Inhibitors
The chemical class termed DDTL Inhibitors comprises a collection of compounds capable of potentially inhibiting the function of the DDTL protein, either directly or indirectly. While direct inhibitors specifically targeting DDTL may not be readily available, these compounds offer insights into potential strategies for modulating DDTL activity through indirect means. DDTL is primarily involved in heme detoxification pathways, essential for the survival and virulence of various pathogens, including malaria parasites and certain fungi. Therefore, compounds such as amodiaquine, primaquine, and hydroxychloroquine, which interfere with heme metabolism and disrupt the formation of hemozoin, indirectly impact DDTL function by altering the availability of its substrate.
Additionally, compounds like disulfiram and acetaminophen can potentially inhibit DDTL by forming covalent bonds with cysteine residues or serving as substrates for the enzyme, respectively. These interactions may disrupt the native conformation of DDTL or lead to enzyme inactivation, thereby interfering with its catalytic activity. Furthermore, fluconazole and antiparasitic drugs such as albendazole can indirectly inhibit DDTL by interfering with heme metabolism, particularly in fungal and parasitic organisms reliant on heme for growth and survival. Collectively, these inhibitors provide valuable avenues for further exploration into the biochemical and physiological roles of DDTL.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Amodiaquine | 86-42-0 | sc-207282 | 10 mg | $342.00 | 1 | |
Amodiaquine is an antimalarial medication that can potentially inhibit DDTL indirectly by interfering with heme metabolism. It disrupts the production of hemozoin, a detoxification byproduct of heme degradation in malaria parasites, which may impact the function of DDTL involved in heme detoxification pathways. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram is an alcohol deterrent drug that can potentially inhibit DDTL by forming disulfide bonds with cysteine residues in the protein structure. This covalent modification can disrupt the native conformation of DDTL, affecting its catalytic activity in detoxifying heme or other substrates. | ||||||
8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline | 90-34-6 | sc-483239 | 1 g | $360.00 | 1 | |
Primaquine, an antimalarial medication, can potentially inhibit DDTL indirectly by interfering with heme metabolism. Similar to amodiaquine, it disrupts the formation of hemozoin, which may lead to alterations in heme detoxification pathways where DDTL plays a role. | ||||||
Acetaminophen | 103-90-2 | sc-203425 sc-203425A sc-203425B | 5 g 100 g 500 g | $40.00 $60.00 $190.00 | 11 | |
Acetaminophen, commonly used as a pain reliever and fever reducer, can potentially inhibit DDTL by serving as a substrate for the enzyme. Metabolism of acetaminophen by DDTL may lead to enzyme inactivation or formation of toxic metabolites, thereby interfering with its normal function. | ||||||
Diclofenac Sodium | 15307-79-6 | sc-202136 sc-202136A | 5 g 25 g | $40.00 $125.00 | 4 | |
Diclofenac, a nonsteroidal anti-inflammatory drug (NSAID), can potentially inhibit DDTL by serving as a substrate for the enzyme. Similar to acetaminophen, metabolism of diclofenac by DDTL may lead to enzyme inactivation or formation of toxic metabolites, thereby interfering with its normal function. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine, an antimalarial and immunomodulatory medication, can potentially inhibit DDTL by interfering with heme metabolism. Its action may disrupt the formation of hemozoin, leading to alterations in heme detoxification pathways where DDTL plays a role. | ||||||
Fluconazole | 86386-73-4 | sc-205698 sc-205698A | 500 mg 1 g | $53.00 $84.00 | 14 | |
Fluconazole, an antifungal medication, can potentially inhibit DDTL indirectly by interfering with heme metabolism. Disruption of hemozoin formation by fluconazole may impact the function of DDTL involved in heme detoxification pathways, affecting the viability of fungal cells dependent on heme for growth and survival. | ||||||
Quinidine | 56-54-2 | sc-212614 | 10 g | $102.00 | 3 | |
Quinidine, an antiarrhythmic medication, can potentially inhibit DDTL indirectly by interfering with heme metabolism. Similar to primaquine and amodiaquine, it disrupts the formation of hemozoin, which may lead to alterations in heme detoxification pathways where DDTL plays a role. | ||||||
Albendazole | 54965-21-8 | sc-210771 | 100 mg | $209.00 | 1 | |
Albendazole, an antiparasitic medication, can potentially inhibit DDTL indirectly by interfering with heme metabolism. Its action may disrupt the formation of hemozoin, leading to alterations in heme detoxification pathways where DDTL plays a role, particularly in parasitic organisms susceptible to heme toxicity. | ||||||