DCI Inhibitors
DCI inhibitors are a class of chemical compounds that target and inhibit DCI (Dodecenoyl-CoA Isomerase), an enzyme involved in the β-oxidation of unsaturated fatty acids within mitochondria. DCI specifically catalyzes the isomerization of cis-Δ3-enoyl-CoA to trans-Δ2-enoyl-CoA, a critical step in the metabolism of mono- and polyunsaturated fatty acids. This enzyme ensures that unsaturated fatty acids are properly processed through the β-oxidation pathway, converting them into acetyl-CoA, which can then be used for energy production. Inhibitors of DCI block this isomerization process, leading to a disruption in the breakdown of unsaturated fatty acids, which can affect energy production and lipid metabolism within the cell.
Inhibiting DCI provides valuable insights into the regulation of fatty acid metabolism and its broader role in cellular energy homeostasis. By blocking DCI activity, researchers can study the accumulation of intermediate fatty acid metabolites and the subsequent impact on mitochondrial function and overall energy balance. DCI inhibition also allows for a more detailed examination of the metabolic pathways involved in the degradation of unsaturated fats, helping to clarify how different enzymes coordinate within these complex biochemical networks. This makes DCI inhibitors an important tool for understanding the intricacies of lipid metabolism, particularly the specific steps and regulatory mechanisms that govern the processing of unsaturated fatty acids in cellular energy pathways.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a morpholine derivative that acts as a specific inhibitor of phosphoinositide 3-kinases (PI3Ks), leading to the suppression of the PI3K/Akt pathway, which can regulate DCI protein activity by altering cell survival and growth signals. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin, a steroid metabolite produced by fungi, is a potent and irreversible PI3K inhibitor, which can impede the PI3K/Akt signaling pathway, thereby affecting the DCI protein activity involved with cellular growth and metabolism. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a synthetic compound that inhibits MEK1/2, leading to the blockade of the ERK/MAPK pathway. This pathway's inhibition can influence the DCI protein function related to cell differentiation and proliferation. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of both MEK1 and MEK2, which can prevent the activation of the ERK/MAPK pathway. By doing so, it can alter the regulation of the DCI protein associated with cellular proliferation and differentiation processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a pyridinyl imidazole compound that selectively inhibits p38 MAP kinase. This inhibition can affect the DCI protein activity if it is regulated through stress response pathways mediated by the p38 MAPK signaling. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an anthrapyrazolone inhibitor of c-Jun N-terminal kinase (JNK), which can disrupt the JNK signaling pathway and, in turn, influence DCI protein activity involved in stress responses and apoptosis. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is a macrolide compound that binds to FKBP12 and inhibits the mTOR pathway, which can alter cell growth and proliferation signals potentially linked to the DCI protein's activity. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src family tyrosine kinases. The inhibition of Src kinase activity can affect various cellular processes, including those that regulate DCI protein activity. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG490 is an ergoline derivative that functions as a selective inhibitor of JAK2 kinase, which can impede JAK/STAT signaling pathways and thereby affect the DCI protein's activity associated with cell growth and differentiation signals. | ||||||
KN-93 | 139298-40-1 | sc-202199 | 1 mg | $178.00 | 25 | |
KN-93 is a synthetic compound that selectively inhibits CaMKII (calcium/calmodulin-dependent protein kinase II). This inhibition can modulate calcium-mediated signaling pathways which in turn can influence DCI protein activity. | ||||||