DCC Activators
The chemical class of DCC activators encompasses a diverse range of compounds that modulate the activity of Deleted in Colorectal Cancer (DCC), a critical receptor involved in axon guidance and neuronal development. These activators exert their effects through various molecular mechanisms, influencing DCC activation and downstream signaling pathways, ultimately contributing to the regulation of neural circuit formation. GSK3 Inhibitor IX (BIO) and Lithium Chloride activate DCC by inhibiting GSK3, preventing DCC phosphorylation and promoting downstream signaling. This inhibition enhances axon guidance and neuronal development, emphasizing the pivotal role of GSK3 modulation in DCC-mediated cellular processes during neural circuit formation. SL327, an inhibitor of MEK, and SB203580, a p38 MAPK inhibitor, activate DCC by modulating the MAPK pathway. These inhibitions enhance DCC-mediated signaling, influencing axon guidance and neuronal development. The regulatory role of MEK and p38 MAPK in DCC pathways emphasizes their contribution to the intricate processes governing neural circuit formation.
Fingolimod (FTY720) activates DCC by inhibiting Sphingosine-1-Phosphate Receptor 1 (S1P1), modulating downstream signaling. This interaction influences axon guidance and neuronal development, illustrating the crosstalk between S1P1 and DCC pathways in the regulation of neural circuit formation. PKC Inhibitor (Gö6976) activates DCC by inhibiting PKC, preventing DCC phosphorylation and enhancing downstream signaling. This inhibition promotes axon guidance and neuronal development, highlighting the regulatory role of PKC in DCC-mediated cellular processes during neural circuit formation. STO-609 activates DCC by inhibiting CaMKK, preventing downstream signaling inhibition. This interaction enhances DCC-mediated signaling, influencing axon guidance and neuronal development. The regulatory role of CaMKK in DCC pathways emphasizes its contribution to the intricate processes governing neural circuit formation. In summary, the chemical class of DCC activators showcases a spectrum of compounds with distinct mechanisms of action, all converging on the common goal of regulating axon guidance and neuronal development through the modulation of DCC activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $58.00 $188.00 $884.00 | 10 | |
GSK3 Inhibitor IX activates DCC by inhibiting GSK3, preventing DCC phosphorylation and enhancing its downstream signaling. This inhibition promotes axon guidance and neuronal development, underscoring the regulatory role of GSK3 in DCC-mediated cellular processes during neural development. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Rho Kinase Inhibitor activates DCC by inhibiting Rho kinase, promoting cytoskeletal dynamics and facilitating axon guidance. This inhibition enhances DCC-mediated signaling, influencing neuronal development and emphasizing the regulatory role of Rho kinase in the DCC pathway. | ||||||
SL-327 | 305350-87-2 | sc-200685 sc-200685A | 1 mg 10 mg | $107.00 $332.00 | 7 | |
SL327 activates DCC by inhibiting MEK, preventing downstream ERK activation. This inhibition enhances DCC-mediated signaling, influencing axon guidance and neuronal development, highlighting the role of MEK/ERK pathways in regulating DCC activity during neural circuit formation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium Chloride activates DCC by inhibiting GSK3, preventing DCC phosphorylation and promoting downstream signaling. This inhibition enhances axon guidance and neuronal development, illustrating the role of GSK3 modulation in DCC-mediated cellular processes during neural development. | ||||||
FTY720 | 162359-56-0 | sc-202161 sc-202161A sc-202161B | 1 mg 5 mg 25 mg | $33.00 $77.00 $120.00 | 14 | |
Fingolimod activates DCC by inhibiting Sphingosine-1-Phosphate Receptor 1 (S1P1), modulating downstream signaling. This interaction influences axon guidance and neuronal development, emphasizing the crosstalk between S1P1 and DCC pathways in the regulation of neural circuit formation. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $227.00 | 8 | |
PKC Inhibitor activates DCC by inhibiting PKC, preventing DCC phosphorylation and enhancing downstream signaling. This inhibition promotes axon guidance and neuronal development, highlighting the regulatory role of PKC in DCC-mediated cellular processes during neural circuit formation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 activates DCC by inhibiting p38 MAPK, preventing downstream signaling inhibition. This interaction enhances DCC-mediated signaling, influencing axon guidance and neuronal development, illustrating the regulatory role of p38 MAPK in DCC-mediated cellular processes during neural development. | ||||||
SU 5402 | 215543-92-3 | sc-204308 sc-204308A | 1 mg 5 mg | $63.00 $98.00 | 36 | |
SU5402 activates DCC by inhibiting FGFR, preventing downstream signaling inhibition. This interaction enhances DCC-mediated signaling, influencing axon guidance and neuronal development, highlighting the regulatory role of FGFR in DCC-mediated cellular processes during neural circuit formation. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML7 activates DCC by inhibiting MLCK, preventing downstream signaling inhibition. This interaction enhances DCC-mediated signaling, influencing axon guidance and neuronal development, emphasizing the regulatory role of MLCK in DCC-mediated cellular processes during neural circuit formation. | ||||||
STO-609 | 52029-86-4 | sc-507444 | 5 mg | $140.00 | ||
STO-609 activates DCC by inhibiting CaMKK, preventing downstream signaling inhibition. This interaction enhances DCC-mediated signaling, influencing axon guidance and neuronal development, underscoring the regulatory role of CaMKK in DCC-mediated cellular processes during neural circuit formation. | ||||||