DCAR1 Inhibitors
DCAR1 (DNA Damage Response-Associated Regulator 1) stands as a crucial sentinel in the cellular response to DNA damage, orchestrating a finely tuned network of pathways aimed at maintaining genomic integrity. As a pivotal component of the DNA damage response (DDR), DCAR1 plays a multifaceted role in sensing, transducing signals, and coordinating appropriate cellular outcomes following genotoxic insults. Inhibition of DCAR1 necessitates a strategic approach, considering its involvement in diverse cellular processes triggered by DNA damage.
The chemical class known as DCAR1 Inhibitors comprises compounds targeting key aspects of DNA repair and replication pathways. For instance, Bleomycin induces DNA strand breaks, perturbing the genomic landscape and indirectly affecting DCAR1 by triggering a cascade of responses to repair DNA lesions. Cisplatin, through the formation of DNA adducts, disrupts DNA repair mechanisms, leading to an indirect impact on DCAR1 function. These inhibitors collectively contribute to dysregulating DDR, influencing DCAR1-mediated signaling pathways crucial for preserving genomic stability. Understanding the intricate interplay between DCAR1 and its inhibitors provides insights into potential strategies for manipulating cellular responses to DNA damage. While the detailed molecular mechanisms of DCAR1 inhibition by these chemicals may vary, the overarching consequence is a compromise in the cell's ability to sense and repair DNA damage adequately. This knowledge underscores the importance of DCAR1 in maintaining genomic integrity and offers avenues for further exploration in cancer research and interventions targeting aberrant DNA damage responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Bleomycin | 11056-06-7 | sc-507293 | 5 mg | $275.00 | 5 | |
Bleomycin induces DNA strand breaks, causing DNA damage and apoptosis. Its indirect impact on DCAR1 involves inducing DNA damage, potentially affecting the protein's role in monitoring and responding to genotoxic stress. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms DNA adducts, causing DNA crosslinking and apoptosis. Its indirect influence on DCAR1 involves disrupting DNA repair mechanisms, potentially impacting the protein's role in maintaining genomic integrity. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin intercalates DNA, causing DNA damage and apoptosis. Its indirect modulation of DCAR1 involves inducing DNA damage, potentially influencing the protein's function in monitoring and responding to genotoxic stress. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, causing DNA strand breaks and apoptosis. Its indirect impact on DCAR1 involves inducing DNA damage, potentially affecting the protein's role in monitoring and responding to genotoxic stress. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $37.00 $152.00 | 11 | |
Fluorouracil inhibits thymidylate synthase, disrupting DNA synthesis. Its indirect influence on DCAR1 involves perturbing DNA replication, potentially impacting the protein's role in monitoring and responding to aberrant DNA structures. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea inhibits ribonucleotide reductase, causing DNA synthesis inhibition. Its indirect modulation of DCAR1 involves disrupting DNA replication, potentially influencing the protein's function in monitoring and responding to aberrant DNA structures. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate inhibits dihydrofolate reductase, disrupting DNA synthesis. Its indirect impact on DCAR1 involves perturbing DNA replication, potentially affecting the protein's role in monitoring and responding to aberrant DNA structures. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $66.00 $101.00 $143.00 | 85 | |
Mitomycin C forms DNA crosslinks, inhibiting DNA replication and inducing apoptosis. Its indirect influence on DCAR1 involves inducing DNA damage, potentially impacting the protein's role in monitoring and responding to genotoxic stress. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib inhibits poly(ADP-ribose) polymerase (PARP), preventing DNA repair. Its indirect modulation of DCAR1 involves disrupting DNA repair mechanisms, potentially affecting the protein's role in maintaining genomic integrity. | ||||||
Temozolomide | 85622-93-1 | sc-203292 sc-203292A | 25 mg 100 mg | $91.00 $255.00 | 32 | |
Temozolomide inhibits DNA repair by methylating guanine, inducing apoptosis. Its indirect impact on DCAR1 involves disrupting DNA repair mechanisms, potentially impacting the protein's role in maintaining genomic integrity. | ||||||