DC-TM4F2 Activators
DC-TM4F2 Activators are a collection of compounds that influence various signaling pathways and cellular processes, leading to the enhanced functional activity of DC-TM4F2. Forskolin contributes to the activation ofDC-TM4F2 Activators by increasing intracellular cAMP, which in turn activates PKA, potentially resulting in the phosphorylation and activation of DC-TM4F2. Epigallocatechin gallate (EGCG), known for its kinase inhibitory properties, could also facilitate DC-TM4F2 activation by suppressing competing signaling cascades, thereby allowing pathways involving DC-TM4F2 to be more active. Sphingosine-1-phosphate (S1P) and Phorbol 12-myristate 13-acetate (PMA) both influence DC-TM4F2 activity through their roles as signaling molecules; S1P via G protein-coupled receptors leading to downstream phosphorylation events, and PMA through activation of PKC, which may result in enhanced DC-TM4F2 activity. Thapsigargin and A23187 (Calcimycin) elevate the cytosolic calcium concentration, which can trigger the activation of calcium-dependent kinases that may subsequently enhance DC-TM4F2 functionality.
Additionally, LY294002 and Wortmannin, as PI3K inhibitors, could lead to a redistribution of cellular signaling pathways, favoring those involving DC-TM4F2 and potentially enhancing its activity. The selective inhibition of MEK1/2 by U0126 and the specific inhibition of p38 MAPK by SB203580 may alter the signaling landscape in a way that promotes the activity of DC-TM4F2, either through compensatory signaling mechanisms or by reducing negative feedback loops. Staurosporine, despite its general kinase inhibition, might preferentially allow the activation of DC-TM4F2-associated pathways by releasing specific kinases that otherwise suppress these routes. Lastly, Genistein's ability to inhibit tyrosine kinases may enhance DC-TM4F2 activity by diminishing the impact of tyrosine kinase-mediated signaling, potentially allowing DC-TM4F2-related pathways to become more prominent within the cellular signaling network. Together, these DC-TM4F2 Activators bolster the functional activity of DC-TM4F2 through a diverse array of biochemical mechanisms, all converging to amplify its role in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin, a labdane diterpene, is known to increase intracellular cAMP levels. The elevation of cAMP activates protein kinase A (PKA), which can phosphorylate various proteins. Through PKA activation, DC-TM4F2 is indirectly activated as PKA phosphorylation can lead to changes in the protein conformation or function, enhancing its activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin gallate (EGCG) is a catechin found in green tea with kinase inhibition properties. By inhibiting certain kinases, EGCG can reduce competitive signaling pathways and indirectly upregulate signaling pathways in which DC-TM4F2 is involved, thus enhancing its activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate (S1P) functions as a signaling lipid and activates G protein-coupled receptors. Activation of these receptors can lead to downstream effects, including the phosphorylation of proteins involved in DC-TM4F2 pathways, ultimately enhancing the functional activity of DC-TM4F2. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diester of phorbol and acts as a potent activator of protein kinase C (PKC). PKC activation can lead to increased phosphorylation of proteins within the signaling pathways of DC-TM4F2, thereby enhancing DC-TM4F2's activity. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that disrupts calcium homeostasis by inhibiting the calcium ATPase of the endoplasmic reticulum. The resulting increase in cytosolic calcium can activate calcium-dependent kinases, which in turn can enhance DC-TM4F2 activity through phosphorylation or changes in the cellular environment. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum protein kinase inhibitor. Even though it generally inhibits kinases, it can lead to the selective activation of pathways where DC-TM4F2 is involved by lifting the inhibition exerted by specific kinases on those pathways, thus indirectly enhancing DC-TM4F2 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a selective inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 can alter downstream signaling pathways, potentially leading to an enhancement of DC-TM4F2 activity by changing the dynamic of the signaling network in which DC-TM4F2 is involved. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 specifically inhibits MEK1/2, which are upstream of ERK in the MAPK pathway. This inhibition can lead to altered pathway dynamics, potentially redirecting signaling to enhance the activity of proteins like DC-TM4F2 through compensatory mechanisms within the cell. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $30.00 $125.00 $445.00 | 45 | |
SB203580 is a specific inhibitor of p38 MAPK. Inhibition of p38 can lead to the redirection of signaling pathways, possibly enhancing DC-TM4F2 activity by allowing signaling through alternative pathways that involve DC-TM4F2. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $54.00 $128.00 $199.00 $311.00 | 23 | |
A23187 is an ionophore that selectively increases intracellular calcium levels. Elevated calcium can activate calcium-dependent kinases and phosphatases, which may enhance the activity of DC-TM4F2 through phosphorylation events or other regulatory mechanisms. | ||||||