DAF-18 Activators
DAF-18 Activators modulate various signaling pathways in a manner that can result in increased activity of DAF-18. These activators function by either inhibiting downstream signaling molecules or by altering metabolic states that lead to a compensatory increase in DAF-18's phosphatase activity. For example, PI3K inhibitors such as LY294002 and Wortmannin reduce the levels of PIP3, leading to decreased AKT phosphorylation and activity. This reduction may alleviate the inhibitory effects on DAF-18, thus increasing its activity.
Furthermore, agents like Metformin and AICAR activate AMPK, which is known to modulate energy balance within cells. This modulation can result in a negative impact on mTOR signaling, leading to increased DAF-18 activity as a feedback mechanism. The goal of these activators is to restore cellular homeostasis by enhancing DAF-18's role in controlling the PI3K/AKT pathway. Resveratrol and curcumin, through their diverse effects on cellular metabolism and inflammation, also contribute to the regulation of this pathway, which may indirectly lead to the enhancement of DAF-18 activity. Omega-3 fatty acids, known for their role in altering inflammation and metabolism, could similarly modulate DAF-18 activity, although their specific mechanisms of action remain to be fully elucidated.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK, part of the MAPK/ERK pathway, which is separate from the PI3K/AKT pathway, so its effects on DAF-18/PTEN are not direct; however, if there is any crosstalk that inhibits PTEN function, then U0126 could relieve that inhibition | ||||||
1,1-Dimethylbiguanide, Hydrochloride | 1115-70-4 | sc-202000F sc-202000A sc-202000B sc-202000C sc-202000D sc-202000E sc-202000 | 10 mg 5 g 10 g 50 g 100 g 250 g 1 g | $20.00 $43.00 $63.00 $156.00 $260.00 $510.00 $31.00 | 37 | |
An AMPK activator, which can reduce mTOR signaling, potentially causing a compensatory upregulation of DAF-18. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Can activate sirtuins leading to improved insulin sensitivity, potentially enhancing DAF-18 activity to maintain energy balance. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
A JNK inhibitor, which could increase DAF-18 activity indirectly through stress response pathways. | ||||||
BEZ235 | 915019-65-7 | sc-364429 | 50 mg | $211.00 | 8 | |
A dual PI3K/mTOR inhibitor, potentially increasing DAF-18 activity by broadly suppressing the pathway. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Can modulate multiple cellular processes and might enhance DAF-18 activity by influencing inflammatory signaling pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
An AMPK agonist, which may upregulate DAF-18 activity through AMPK's role in energy homeostasis. | ||||||