D030016E14Rik Inhibitors
Trappc11, predicted to be involved in the constitutive secretory pathway, endoplasmic reticulum to Golgi vesicle-mediated transport, and regulation of protein complex stability, is an essential component of the TRAPP complex. The TRAPP complex plays a crucial role in vesicle-mediated transport between the endoplasmic reticulum and the Golgi apparatus. The identified inhibitors target specific aspects of vesicle-mediated transport and Golgi function. Brefeldin A directly inhibits Trappc11 by disrupting ARF-dependent vesicular trafficking, preventing endoplasmic reticulum to Golgi transport. Exo1, an exocyst complex inhibitor, interferes with vesicle tethering, impairing Golgi transport and the constitutive secretory pathway. Monensin disrupts Golgi function and endoplasmic reticulum to Golgi vesicle-mediated transport. Golgicide A interferes with ARFGEF-mediated vesicle formation, directly inhibiting Trappc11.
Sar1 inhibitor I directly hinders Trappc11 by disrupting the initial steps of COPII vesicle formation crucial for endoplasmic reticulum to Golgi transport. N-Ethylmaleimide, a cysteine protease inhibitor, indirectly influences Trappc11 by disrupting vesicular transport processes affecting the constitutive secretory pathway. ARF6 Inhibitor disrupts ARF6-dependent vesicle trafficking, impacting Golgi transport and Trappc11 function. Golgin-84 Inhibitor directly impacts Trappc11 by disrupting Golgin-84-mediated vesicular tethering, affecting Golgi transport and the constitutive secretory pathway. Y27632, a ROCK inhibitor, indirectly influences Trappc11 by disrupting actin cytoskeleton dynamics essential for vesicle-mediated transport. GBF1 Inhibitor directly hinders Trappc11 by disrupting GBF1-dependent vesicle formation, impacting endoplasmic reticulum to Golgi transport. Methylamine indirectly influences Trappc11 by disrupting Golgi function and vesicle-mediated transport, affecting the constitutive secretory pathway. EHT1864, a Rac family small GTPase inhibitor, indirectly influences Trappc11 by disrupting actin cytoskeleton dynamics essential for vesicle-mediated transport. These inhibitors offer valuable tools to dissect the intricate regulation of TRAPP complex-mediated vesicular transport and its impact on cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A, an ADP-ribosylation factor (ARF) inhibitor, directly inhibits Trappc11 by disrupting the ARF-dependent vesicular trafficking, preventing endoplasmic reticulum to Golgi transport. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Exo1, an exocyst complex inhibitor, directly hinders Trappc11 by disrupting vesicle tethering, impairing Golgi transport and constitutive secretory pathway. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin, a sodium ionophore, indirectly influences Trappc11 by disrupting Golgi function and endoplasmic reticulum to Golgi vesicle-mediated transport. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A, an ADP-ribosylation factor guanine nucleotide exchange factor (ARFGEF) inhibitor, directly inhibits Trappc11 by interfering with ARFGEF-mediated vesicle formation. | ||||||
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide, a cysteine protease inhibitor, indirectly influences Trappc11 by disrupting vesicular transport processes, affecting the constitutive secretory pathway. | ||||||
Q-VD-OPH | 1135695-98-5 | sc-222230 | 5 mg | $782.00 | 5 | |
Q-VD-OPH, an ADP-ribosylation factor 6 (ARF6) inhibitor, directly inhibits Trappc11 by disrupting ARF6-dependent vesicle trafficking, impacting Golgi transport. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y27632, a Rho-associated protein kinase (ROCK) inhibitor, indirectly influences Trappc11 by disrupting actin cytoskeleton dynamics, essential for vesicle-mediated transport. | ||||||
Exo2 | 304684-77-3 | sc-215011 sc-215011A | 5 mg 25 mg | $89.00 $288.00 | 1 | |
Exo2, a guanine nucleotide exchange factor 1 (GBF1) inhibitor, directly hinders Trappc11 by disrupting GBF1-dependent vesicle formation, impacting endoplasmic reticulum to Golgi transport. | ||||||
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT1864, a Rac family small GTPase inhibitor, indirectly influences Trappc11 by disrupting actin cytoskeleton dynamics, essential for vesicle-mediated transport. | ||||||