CYP4F2 Activators
CYP4F2 activators belong to a class of chemical compounds that interact with and modulate the activity of the cytochrome P450 4F2 enzyme, which is a member of the cytochrome P450 superfamily. This class of enzymes plays a pivotal role in the metabolism of various endogenous and exogenous compounds within the human body. Cytochrome P450 4F2, specifically, is predominantly found in the liver and is known for its involvement in the oxidation of fatty acids and eicosanoids, which are lipid signaling molecules that play crucial roles in inflammation, blood pressure regulation, and vascular homeostasis.
CYP4F2 activators are designed to enhance the enzymatic activity of CYP4F2, leading to increased rates of fatty acid oxidation and the production of specific eicosanoids. These compounds are of particular interest in the context of lipid metabolism and inflammation regulation. By modulating CYP4F2 activity, researchers aim to gain a better understanding of the intricate mechanisms governing lipid homeostasis and inflammatory responses in the body. Additionally, the development of CYP4F2 activators may have potential applications in areas such as cardiovascular research, where dysregulated lipid metabolism and chronic inflammation are implicated in the pathogenesis of various diseases. In summary, CYP4F2 activators represent a class of compounds that hold promise in advancing our understanding of lipid metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Arachidonic Acid (20:4, n-6) | 506-32-1 | sc-200770 sc-200770A sc-200770B | 100 mg 1 g 25 g | $92.00 $240.00 $4328.00 | 9 | |
Arachidonic acid is a natural substrate for CYP4F2. It can enter the enzyme's active site, leading to the production of bioactive lipid mediators, potentially enhancing CYP4F2 activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA indirectly activates CYP4F2 by stimulating protein kinase C (PKC), which in turn can phosphorylate and activate the enzyme, potentially leading to an increase in its catalytic activity. | ||||||
Linoleic Acid | 60-33-3 | sc-200788 sc-200788A sc-200788B sc-200788C | 100 mg 1 g 5 g 25 g | $34.00 $64.00 $166.00 $281.00 | 4 | |
Linoleic acid can serve as a substrate for CYP4F2, and the enzyme can metabolize it to produce various lipid mediators. This metabolic process can enhance CYP4F2 activity. | ||||||
α-Naphthoflavone | 604-59-1 | sc-257037 sc-257037A sc-257037B sc-257037C | 1 g 5 g 25 g 100 g | $34.00 $46.00 $156.00 $500.00 | 3 | |
α-Naphthoflavone is an aryl hydrocarbon receptor (AhR) agonist. Activation of AhR can induce the expression of CYP4F2 and other CYP enzymes, thereby increasing their activity. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin is known to induce CYP enzymes, including CYP4F2, by activating nuclear receptors such as the pregnane X receptor (PXR), leading to increased expression and activity. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone is a synthetic glucocorticoid that can induce CYP enzymes, including CYP4F2, through various signaling pathways, potentially leading to increased enzyme activity. | ||||||
3-Methylcholanthrene | 56-49-5 | sc-252030 sc-252030A | 100 mg 250 mg | $388.00 $831.00 | 2 | |
3-Methylcholanthrene is a polycyclic aromatic hydrocarbon that activates the aryl hydrocarbon receptor (AhR). AhR activation can induce CYP4F2 and enhance its metabolic activity. | ||||||
Aroclor 1254 | 11097-69-1 | sc-257096 | 50 mg | $143.00 | 1 | |
Aroclor 1254 is a mixture of polychlorinated biphenyls (PCBs). Its ability to induce CYP4F2 may be due to its interaction with various cellular receptors and signaling pathways, leading to increased enzyme activity. | ||||||