CYP2E1 Activators
CYP2E1 activators belong to a class of chemical compounds that interact with and influence the activity of the enzyme Cytochrome P450 2E1 (CYP2E1). CYP2E1 is a member of the cytochrome P450 enzyme family, which plays a crucial role in the metabolism of a wide range of endogenous and exogenous compounds within the human body. These enzymes are primarily located in the liver and are involved in the oxidation of various substrates, including drugs, toxins, and environmental pollutants. CYP2E1, in particular, is known for its ability to metabolize a diverse array of compounds, including ethanol, acetaminophen, and various industrial solvents.
CYP2E1 activators are compounds that enhance the enzymatic activity of CYP2E1. This activation can lead to increased metabolism and bioactivation of substances that serve as substrates for CYP2E1. It's important to note that the activation of CYP2E1 can have both beneficial and detrimental effects depending on the context. For example, while the increased metabolism of certain drugs can enhance their clearance from the body, it can also lead to the formation of toxic metabolites. Additionally, the enhanced metabolism of ethanol by CYP2E1 can contribute to the production of harmful reactive oxygen species, which may play a role in ethanol-induced liver damage. The study of CYP2E1 activators is important in the field of pharmacology and toxicology, as it helps researchers understand how various substances can modulate the activity of this enzyme and, consequently, impact the metabolism and toxicity of drugs and other compounds. By elucidating the mechanisms of CYP2E1 activation, scientists can better predict and manage the effects of chemical exposures and develop strategies to mitigate adverse outcomes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
2-Propanol | 67-63-0 | sc-391000C sc-391000 sc-391000B sc-391000A | 1 ml 25 ml 100 ml 500 ml | $33.00 $53.00 $63.00 $89.00 | 1 | |
2-Propanol acts as a CYP2E1 activator by serving as a substrate that increases the enzyme's catalytic activity. | ||||||
Benzyl alcohol | 100-51-6 | sc-326216B sc-326216 sc-326216A | 250 ml 1 L 5 L | $32.00 $104.00 $416.00 | ||
Benzyl Alcohol induces CYP2E1 activity through allosteric modulation, promoting increased enzyme turnover. | ||||||
Chlorzoxazone | 95-25-0 | sc-211078 | 10 mg | $62.00 | ||
Chlorzoxazone activates CYP2E1 by serving as a selective substrate, leading to enhanced enzyme activity. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline, while primarily known for other targets, can upregulate CYP2E1 expression, thereby indirectly increasing its activity. | ||||||
3,5-Dimethylpyrazole | 67-51-6 | sc-238701 | 100 g | $146.00 | ||
3,5-Dimethylpyrazole activates CYP2E1 through competitive binding and increased turnover of enzyme-substrate complexes. | ||||||
Isoniazid | 54-85-3 | sc-205722 sc-205722A sc-205722B | 5 g 50 g 100 g | $26.00 $101.00 $146.00 | ||
Isoniazid can upregulate CYP2E1 expression, thereby indirectly enhancing its enzymatic activity. | ||||||
Acetonitrile | 75-05-8 | sc-207252 sc-207252A | 500 ml 2.5 L | $57.00 $168.00 | 1 | |
Acetonitrile induces CYP2E1 activity by serving as a substrate, thereby enhancing the enzyme's catalytic capacity. | ||||||