CYP2B23 Activators
CYP2B23, a member of the cytochrome P450 family 2 subfamily B, plays a crucial role in xenobiotic metabolism and steroid processes. This enzyme is implicated in various physiological and pathophysiological conditions, including acute myeloid leukemia, human immunodeficiency virus infectious disease, and tuberculosis. The gene encoding CYP2B23 shares homology with the human CYP2B6 ortholog. The primary function of CYP2B23 involves heme binding and monooxygenase activity, contributing to the metabolism of a wide range of exogenous substances.
Activation of CYP2B23 involves the influence of specific chemicals that act as direct or indirect activators. Phenobarbital, a barbiturate, induces CYP2B23 by binding to nuclear receptors and initiating gene expression. Similarly, dexamethasone, a synthetic glucocorticoid, activates CYP2B23 by acting as a glucocorticoid receptor agonist. Rifampicin, an antibiotic, stimulates the pregnane X receptor, leading to increased CYP2B23 transcription. These chemicals, along with others listed, modulate various cellular pathways such as AhR, PXR, and NRF2, indirectly promoting CYP2B23 activation. Such modulation enhances the enzyme's contribution to xenobiotic metabolism and steroid processes, highlighting its role in maintaining cellular homeostasis and responding to environmental challenges. The diverse array of activators provides a nuanced understanding of how CYP2B23 integrates into cellular pathways, offering potential avenues for further research in pharmacology and toxicology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Dexamethasone acts as a glucocorticoid receptor agonist, inducing CYP2B23 expression. By binding to the glucocorticoid receptor, it triggers a cascade of events leading to enhanced transcription of CYP2B23, influencing the steroid metabolic process. This synthetic glucocorticoid serves as a potent indirect activator of CYP2B23 through the modulation of cellular signaling pathways. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $97.00 $328.00 $676.00 $1467.00 | 6 | |
Rifampicin activates CYP2B23 by stimulating the pregnane X receptor (PXR). Through PXR activation, rifampicin upregulates the transcription of CYP2B23, promoting its role in xenobiotic metabolism. This antibiotic is a potent inducer, influencing the xenobiotic catabolic process by modulating the expression of CYP2B23 and other cytochrome P450 enzymes involved in drug metabolism. | ||||||
Omeprazole | 73590-58-6 | sc-202265 | 50 mg | $67.00 | 4 | |
Omeprazole serves as a CYP2B23 activator by affecting the aryl hydrocarbon receptor (AhR) pathway. Binding to AhR, omeprazole initiates a signaling cascade that indirectly upregulates CYP2B23 expression. This proton pump inhibitor demonstrates its ability to modulate the xenobiotic catabolic process by influencing AhR-mediated transcriptional regulation, thus promoting CYP2B23 activation. | ||||||
Naringenin | 480-41-1 | sc-219338 | 25 g | $245.00 | 11 | |
Naringenin acts as a natural flavonoid activator of CYP2B23 by engaging the constitutive androstane receptor (CAR). By binding to CAR, naringenin induces the transcription of CYP2B23, contributing to its upregulation. This flavonoid, found in citrus fruits, serves as a dietary component that can influence the expression of CYP2B23 and enhance its role in xenobiotic metabolism and steroid processes. | ||||||
β-Naphthoflavone | 6051-87-2 | sc-205597 sc-205597A sc-205597B sc-205597C | 1 g 5 g 25 g 100 g | $33.00 $129.00 $599.00 $1647.00 | 2 | |
β-Naphthoflavone is a potent inducer of CYP2B23 through its action on the aryl hydrocarbon receptor (AhR). By binding to AhR, β-naphthoflavone triggers a signaling cascade leading to the upregulation of CYP2B23 transcription. This polycyclic aromatic hydrocarbon derivative serves as a xenobiotic that can influence the AhR pathway, thereby indirectly promoting CYP2B23 activation and enhancing its metabolic functions. | ||||||
Aroclor 1254 | 11097-69-1 | sc-257096 | 50 mg | $143.00 | 1 | |
Aroclor 1254 acts as an indirect activator of CYP2B23 through its influence on the aryl hydrocarbon receptor (AhR) pathway. By binding to AhR, Aroclor 1254 initiates a signaling cascade that leads to the upregulation of CYP2B23 transcription. This polychlorinated biphenyl mixture serves as an environmental contaminant that can modulate the AhR pathway, thereby indirectly promoting CYP2B23 activation and enhancing its role in xenobiotic metabolism. | ||||||
Carbamazepine | 298-46-4 | sc-202518 sc-202518A | 1 g 5 g | $33.00 $71.00 | 5 | |
Carbamazepine acts as an activator of CYP2B23 by inducing the pregnane X receptor (PXR). Through PXR activation, carbamazepine upregulates the transcription of CYP2B23, contributing to the enhancement of xenobiotic metabolism. This anticonvulsant drug serves as a modulator of PXR-mediated signaling, influencing the pregnane X receptor pathway and promoting CYP2B23 activity in drug metabolism. | ||||||
6-Phenyl-2-thiouracil | 36822-11-4 | sc-207131 | 1 g | $231.00 | ||
6-Phenyl-2-thiouracil serves as an indirect activator of CYP2B23 by influencing the thyroid hormone receptor (THR) pathway. By modulating THR signaling, this thiouracil derivative indirectly upregulates CYP2B23 transcription. The chemical structure of 6-phenyl-2-thiouracil allows it to interact with THR, thereby promoting the activation of CYP2B23 and contributing to its role in xenobiotic metabolism and steroid processes. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
Ellagic Acid acts as an activator of CYP2B23 by modulating the nuclear factor erythroid 2-related factor 2 (NRF2) pathway. Through its influence on NRF2 signaling, ellagic acid upregulates the transcription of CYP2B23, contributing to its activation. This polyphenolic compound serves as a dietary component that can modulate cellular pathways, indirectly promoting CYP2B23 activity in xenobiotic metabolism and enhancing its role in oxidative stress response. | ||||||