CYP27B1 Activators
CYP27B1 activators are a class of chemical compounds that play a crucial role in regulating the activation of the enzyme cytochrome P450 family 27 subfamily B member 1 (CYP27B1), also known as 25-hydroxyvitamin D3 1-alpha-hydroxylase. These activators are primarily associated with the control of vitamin D metabolism within the human body. CYP27B1 is primarily expressed in the kidney and various immune cells, where it catalyzes the conversion of 25-hydroxyvitamin D3 (calcidiol) into its biologically active form, 1,25-dihydroxyvitamin D3 (calcitriol). Calcitriol is a potent steroid hormone that plays a pivotal role in regulating calcium and phosphate homeostasis, thus influencing bone health. CYP27B1 activators modulate this enzymatic conversion, impacting the overall levels of calcitriol in the body.
These activators can have diverse chemical structures, but they typically function by enhancing the enzymatic activity of CYP27B1. By doing so, they increase the production of calcitriol, which subsequently exerts its effects on various target tissues, including the intestines, bones, and parathyroid glands. This regulation of calcitriol synthesis is essential for maintaining calcium and phosphate balance in the body, which is crucial for normal bone development and function.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
This compound is the active form of vitamin D and can potentially enhance CYP27B1 expression to maintain adequate levels of active vitamin D in the body. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
This bile acid has been shown to induce the expression of CYP27B1, possibly as a mechanism to enhance the catabolism of toxic sterols. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase and increases cAMP levels, which can lead to the induction of CYP27B1 expression through cAMP-dependent signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid, a metabolite of vitamin A, has been implicated in the regulation of CYP27B1 expression, potentially through retinoic acid receptors. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C, which can lead to the induction of CYP27B1 expression through downstream signaling pathways. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 can be converted to 1,25-dihydroxyvitamin D3 in the body, potentially leading to the induction of CYP27B1 expression. | ||||||
25-Hydroxyvitamin D3 | 19356-17-3 | sc-288574A sc-288574 sc-288574B sc-288574C sc-288574D sc-288574E | 1 mg 5 mg 25 mg 500 mg 1 g 10 g | $108.00 $372.00 $788.00 $1324.00 $2311.00 $12067.00 | 13 | |
This precursor of 1,25-dihydroxyvitamin D3 can potentially induce CYP27B1 expression as part of the regulatory feedback mechanisms for vitamin D metabolism. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
This synthetic glucocorticoid can induce CYP27B1 expression, possibly as a mechanism to enhance the metabolism of vitamin D. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
Rosiglitazone is a PPARγ agonist, and activation of PPARγ has been shown to induce CYP27B1 expression in certain cell types. | ||||||