CT47A12 Activators
The functional activity of B7-H6, a protein crucial for natural killer (NK) cell-mediated cytotoxicity against tumor cells, can be influenced by various compounds that enhance the immune response, particularly involving NK cells. Interleukin-2 (IL-2) and Interleukin-15 (IL-15) are cytokines that stimulate NK cell activity, potentially augmenting the immune response mediated by B7-H6 and NKp30 interaction. IL-2 and IL-15 can increase the proliferation and activation of NK cells, thereby enhancing their ability to recognize and kill B7-H6-expressing tumor cells.
Immunomodulatory drugs like Lenalidomide, Thalidomide, and Pomalidomide can also enhance NK cell activity. These compounds can increase the expression of activating receptors on NK cells, thereby enhancing the NK cell response to B7-H6-expressing cells. Proteasome inhibitors like Bortezomib and Heat Shock Protein 90 (HSP90) inhibitors, such as 17-AAG, can induce stress in tumor cells, potentially leading to increased expression of B7-H6, making these cells more susceptible to NK cell-mediated killing.
Histone Deacetylase (HDAC) inhibitors, including Vorinostat, can influence gene expression in tumor cells and may upregulate B7-H6 expression. This upregulation can enhance the visibility of tumor cells to NK cells. Toll-Like Receptor (TLR) agonists, such as Imiquimod, activate the immune system and may also enhance the expression of ligands like B7-H6 on tumor cells.
Interferons, particularly IFN-alpha and IFN-gamma, are critical in enhancing NK cell activity and may upregulate B7-H6 expression on tumor cells, thus facilitating NK cell-mediated recognition and elimination of these cells. Additionally, monoclonal antibodies targeting NKp30 can specifically enhance the interaction between NK cells and B7-H6-expressing cells, boosting the NK cell-mediated immune response.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lenalidomide | 191732-72-6 | sc-218656 sc-218656A sc-218656B | 10 mg 100 mg 1 g | $50.00 $374.00 $2071.00 | 18 | |
Lenalidomide enhances NK cell activity and can increase the expression of activating receptors on NK cells. This may enhance the NK cell response to B7-H6-expressing cells. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide modulates the immune system and can enhance NK cell activity. This may increase the effectiveness of NK cells interacting with B7-H6. | ||||||
Pomalidomide | 19171-19-8 | sc-364593 sc-364593A sc-364593B sc-364593C sc-364593D sc-364593E | 5 mg 10 mg 50 mg 100 mg 500 mg 1 g | $100.00 $143.00 $312.00 $468.00 $1248.00 $1997.00 | 1 | |
Pomalidomide enhances the immune response, including NK cell activity. This can lead to an increased response to cells expressing B7-H6. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib, a proteasome inhibitor, can induce stress in tumor cells, potentially upregulating B7-H6 expression and enhancing the NK cell-mediated immune response against these cells. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
HSP90 inhibitors can induce stress responses in tumor cells, possibly upregulating B7-H6 expression and enhancing NK cell recognition of stressed or malignant cells. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitors can affect gene expression in tumor cells, potentially influencing B7-H6 expression and increasing the visibility of these cells to NK cells. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
TLR agonists can activate the immune system and may enhance the expression of ligands like B7-H6 on tumor cells, increasing their susceptibility to NK cell-mediated cytotoxicity. | ||||||