Cst9 Activators
Cst9, a member of the cystatin superfamily, encodes a secreted protein with potential roles in hematopoietic differentiation or inflammation. Belonging to the type 2 cystatins, it is involved in inhibiting cysteine proteinases and providing protective functions in various human fluids and secretions. The Cst9 gene, located in the cystatin locus on chromosome 20, is part of a complex superfamily with multiple cystatin-like sequences. Activation of Cst9 involves both direct and indirect mechanisms. Direct activators, such as PMA and forskolin, impact signaling pathways like PKC and AC, leading to enhanced Cst9 expression and secretion. Indirectly, chemicals like dexamethasone and LPS modulate anti-inflammatory and TLR4-mediated pathways, potentially influencing Cst9's role in inflammation and hematopoietic differentiation.
For instance, PMA directly activates Cst9 by stimulating PKC, impacting downstream signaling and modifying Cst9's function. This activation contributes to Cst9's role in hematopoietic differentiation or inflammation, providing protective functions in human fluids and secretions. Understanding these intricate interactions sheds light on the regulatory network governing Cst9 activation and its potential implications in maintaining homeostasis and responding to inflammatory challenges.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PKC activator directly influencing Cst9. Activates PKC, potentially impacting downstream signaling and Cst9 function. Modulates protease inhibitor activity and protective functions in human fluids. Enhances Cst9 expression and secretion, contributing to its role in hematopoietic differentiation or inflammation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $91.00 $139.00 $374.00 | 36 | |
Glucocorticoid receptor activator indirectly impacting Cst9. Activates anti-inflammatory signaling, potentially modulating Cst9 expression and secretion. May contribute to Cst9's role in inflammation, providing protective functions in human fluids. | ||||||
Lipopolysaccharide, E. coli O55:B5 | 93572-42-0 | sc-221855 sc-221855A sc-221855B sc-221855C | 10 mg 25 mg 100 mg 500 mg | $98.00 $171.00 $425.00 $1560.00 | 12 | |
TLR4 agonist indirectly influencing Cst9. Activates inflammatory pathways, potentially modulating Cst9 expression. Enhances Cst9's role in inflammation, providing protective functions in human fluids and contributing to its potential involvement in hematopoietic differentiation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
p38 MAPK inhibitor indirectly influencing Cst9. Suppresses pro-inflammatory signaling, potentially modulating Cst9 expression. Modifies Cst9's role in inflammation and hematopoietic differentiation, contributing to its protective functions in human fluids. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
STAT3 inhibitor indirectly influencing Cst9. Suppresses STAT3 signaling, potentially modulating Cst9 expression and function. Alters Cst9's role in inflammation and hematopoietic differentiation, contributing to its protective functions in human fluids. | ||||||