Cst9 Inhibitors
Cst9 inhibitors are a class of chemical compounds that specifically target the protein Cystatin 9 (CST9), which is part of the cystatin superfamily. Cystatins are known for their role as cysteine protease inhibitors, regulating the activity of enzymes like cathepsins. These enzymes are involved in protein degradation processes that are essential for cellular homeostasis, as they help break down misfolded or damaged proteins. CST9, in particular, is less well-studied compared to other members of the cystatin family, but it is thought to be involved in modulating protease activity in specific biological contexts, potentially linked to immune response and tissue remodeling. Inhibitors of CST9 are designed to disrupt this interaction, affecting the downstream regulation of protease activity.
Cst9 inhibitors are designed to interact with the active site of the CST9 protein, binding to the same region that would typically engage with cysteine proteases. This class of inhibitors can exhibit a range of chemical diversity, with variations in their molecular scaffolds, side chains, and binding affinities. By modulating CST9 activity, these inhibitors can provide insight into the protein's regulatory functions in various physiological processes, particularly those related to proteolysis. The development and study of Cst9 inhibitors contribute to a broader understanding of how cystatins control protease activity at a molecular level, making them a valuable tool in biochemical research, particularly in studies focused on protein degradation and enzyme regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64c is an irreversible cysteine protease inhibitor, directly inhibiting Cst9. By covalently binding to the active site of cysteine proteases, it disrupts their enzymatic activity, indirectly affecting Cst9's role in protease inhibition. This inhibition may have implications in hematopoietic differentiation or inflammation by perturbing protease-mediated processes. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is a reversible cysteine protease inhibitor, directly inhibiting Cst9. By binding to the active site of cysteine proteases, it interferes with their enzymatic activity, impacting the regulatory functions of Cst9. This inhibition may have implications in hematopoietic differentiation or inflammation by disrupting protease-mediated processes. | ||||||
CA-074 | 134448-10-5 | sc-202513 | 1 mg | $315.00 | ||
CA-074 Me is a selective inhibitor of cathepsin B, functioning as a direct inhibitor of Cst9. By targeting cathepsin B, it modulates Cst9's regulatory functions, potentially impacting hematopoietic differentiation or inflammation through interference with protease-mediated processes. | ||||||
ALLM (Calpain Inhibitor) | 136632-32-1 | sc-201268 sc-201268A | 5 mg 25 mg | $140.00 $380.00 | 23 | |
ALLM is a reversible inhibitor of cysteine proteases, directly affecting Cst9. By binding to the active site of cysteine proteases, it modulates their enzymatic activity and indirectly impacts Cst9's regulatory functions. This inhibition may have consequences in hematopoietic differentiation or inflammation by disrupting protease-mediated processes. | ||||||