CSNK1A1L Inhibitors
CSNK1A1L Inhibitors largely focus on the broader CK1 family or on closely related kinases. Their primary mode of action is to impede the kinase activity of these proteins, thus altering the subsequent signaling cascades in which they play a role.
D4476, IC261, CKI-7, Apigenin, and Lavendustin B are chemicals that specifically target CK1 kinase activity. Their presence can disrupt the normal phosphorylation of substrates by CK1 proteins, and by extension, CSNK1A1L. In this way, they act as direct inhibitors, reducing the activity of the enzyme and its downstream signaling. Another group of chemicals, including TBB, DRB, Silmitasertib, Emodin, Quinalizarin, DMAT, and Epigallocatechin gallate, primarily target CK2, which is closely related to CK1. While these are not direct inhibitors of CSNK1A1L, the proximity in function between CK1 and CK2 means that disruption of CK2 activity can have indirect effects on CK1 pathways, potentially affecting CSNK1A1L's function or its regulation.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Casein Kinase I Inhibitor, D4476 | 301836-43-1 | sc-202522 | 1 mg | $99.00 | 6 | |
CK1 inhibitor that can block kinase activity. | ||||||
IC261 | 186611-52-9 | sc-3561 | 5 mg | $140.00 | 11 | |
CK1-specific inhibitor that affects protein kinase activity. | ||||||
CKI-7 dihydrochloride | 1177141-67-1 | sc-252621 sc-252621A | 5 mg 10 mg | $280.00 $320.00 | 5 | |
Inhibits CK1 kinase activity. | ||||||
TBB | 17374-26-4 | sc-202830 sc-202830A sc-202830C sc-202830B sc-202830D | 10 mg 25 mg 50 mg 100 mg 250 mg | $245.00 $370.00 $454.00 $760.00 $1817.00 | 17 | |
Inhibitor of CK2, a close relative of CK1, and may influence CK1 activity. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Affects CK2 activity, might indirectly influence CK1. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
CK1 inhibitor affecting kinase activity. | ||||||
Lavendustin B | 125697-91-8 | sc-200595 sc-200595A | 1 mg 5 mg | $64.00 $249.00 | 1 | |
Affects CK1 kinase activity. | ||||||
CX-4945 | 1009820-21-6 | sc-364475 sc-364475A | 2 mg 50 mg | $183.00 $800.00 | 9 | |
Primarily a CK2 inhibitor but can influence CK1 indirectly. | ||||||
Emodin | 518-82-1 | sc-202601 sc-202601A sc-202601B | 50 mg 250 mg 15 g | $105.00 $214.00 $6255.00 | 2 | |
CK2 inhibitor that may indirectly impact CK1. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Inhibits CK2, may have indirect effects on CK1. | ||||||