Date published: 2026-5-30

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Crossveinless-2 Inhibitors

Crossveinless-2 Inhibitors belong to a specific chemical class that plays a crucial role in modulating biological processes associated with angiogenesis and vascular development. At the heart of this class is the protein Crossveinless-2 (CV2), which functions as an extracellular matrix component and a key regulator of signaling pathways involved in the formation of blood vessels. Crossveinless-2 Inhibitors exert their influence by selectively targeting and suppressing the activity of CV2, thereby fine-tuning intricate cellular mechanisms that govern angiogenesis. This chemical class is characterized by its ability to interfere with the binding interactions and downstream signaling cascades associated with CV2, ultimately leading to altered vascular patterning during development. Crossveinless-2 Inhibitors extends beyond their molecular interactions, as they hold promise for unraveling the complexities of angiogenesis and vascular morphogenesis. Researchers focus on understanding the detailed mechanisms by which these inhibitors modulate CV2 function, shedding light on the intricate regulatory networks that underlie blood vessel formation. The exploration of Crossveinless-2 Inhibitors serves as a critical avenue for deciphering the molecular underpinnings of vascular biology, offering valuable insights into the delicate balance required for proper angiogenesis. As scientists delve deeper into the intricate web of signaling pathways influenced by these inhibitors, the potential for uncovering novel strategies to manipulate vascular development and address related physiological processes becomes increasingly evident.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

DMH-1

1206711-16-1sc-361171
sc-361171B
sc-361171A
sc-361171C
10 mg
25 mg
50 mg
100 mg
$213.00
$318.00
$632.00
$1047.00
2
(0)

Another selective BMP type I receptor inhibitor targeting ALK2, impeding the BMP signaling pathway.

BML-275

866405-64-3sc-200689
sc-200689A
5 mg
25 mg
$96.00
$355.00
69
(1)

The first identified small molecule inhibitor of BMP signaling; it inhibits BMP type I receptors ALK2, ALK3, and ALK6.

K02288

1431985-92-0sc-488981
5 mg
$330.00
(0)

A potent and selective inhibitor of ALK2 and ALK3 that can suppress BMP signaling.

LDN-214117

1627503-67-6sc-507451
5 mg
$165.00
(0)

A selective inhibitor of ALK2 that can disrupt BMP signaling mediated by BMPER interaction with BMPs.

SB 431542

301836-41-9sc-204265
sc-204265A
sc-204265B
1 mg
10 mg
25 mg
$82.00
$216.00
$416.00
48
(1)

An inhibitor that can indirectly reduce BMP signaling by inhibiting TGF-β type I receptors, which share signaling components with BMP pathways.

LDN 193719

1062368-49-3sc-489383
10 mg
$189.00
(0)

A selective inhibitor for ALK1 and ALK2, which are involved in BMP signaling, possibly affecting BMPER's regulatory role.

A 83-01

909910-43-6sc-203791
sc-203791A
10 mg
50 mg
$202.00
$811.00
16
(1)

A selective inhibitor of ALK4, ALK5, and ALK7, which can indirectly influence BMP signaling.

Hesperadin

422513-13-1sc-490384
10 mg
$304.00
(0)

An Aurora B kinase inhibitor that can indirectly influence cellular pathways related to BMP signaling.

Thiazovivin

1226056-71-8sc-361380
sc-361380A
10 mg
25 mg
$284.00
$634.00
15
(1)

A Rho kinase inhibitor that can have secondary effects on cellular processes influenced by BMP signaling.

Y-27632, free base

146986-50-7sc-3536
sc-3536A
5 mg
50 mg
$186.00
$707.00
88
(1)

Another Rho kinase inhibitor that can affect cellular dynamics and potentially influence BMP signaling pathways.