CRISP-2 Activators
CRISP-2 Activators are chemicals that may logically enhance the function of the CRISP-2 protein through specific signaling pathways or biological processes that CRISP-2 is directly involved in. All the chemicals listed here are either hormones known to affect sperm function, like Progesterone and Estradiol, or are phosphodiesterase (PDE) inhibitors that increase cAMP or cGMP levels, leading to increased intracellular calcium. Progesterone and Estradiol, two key hormones in reproductive processes, can alter calcium dynamics within sperm cells, which may activate CRISP-2.
Progesterone is known to activate CatSper, a calcium channel on the sperm tail, leading to a calcium influx. Estradiol influences the acrosomal reaction, a process that involves the release of stored calcium. As CRISP-2 is a calcium-binding protein located on the sperm tail, increased calcium levels could directly interact with and activate CRISP-2. On the other hand, chemicals like Tadalafil, Sildenafil, Forskolin, Cilostazol, Rolipram, Vinpocetine, Zardaverine, Milrinone, Etazolate, and Theophylline are all PDE inhibitors that lead to increased levels of cAMP or cGMP, which subsequently raise intracellular calcium levels. The increase in calcium levels could potentially activate CRISP-2, given its ability to bind calcium.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $51.00 $292.00 | 3 | |
Progesterone can enhance the calcium influx in sperm cells by activating CatSper, a calcium channel on the sperm tail. CRISP-2, positioned on the sperm tail, can potentially be activated due to this increased calcium influx, as calcium ions are known to interact with the CRISP family of proteins. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
Estradiol can influence the acrosomal reaction in sperm cells, which involves the release of stored calcium. This calcium surge could potentially interact with CRISP-2, known to be calcium-binding, and enhance its activity. | ||||||
Tadalafil | 171596-29-5 | sc-208412 | 50 mg | $176.00 | 13 | |
Tadalafil, a PDE5 inhibitor, leads to elevated levels of cGMP and, subsequently, increased intracellular calcium. This surge in calcium may interact with CRISP-2, activating the protein. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates cAMP levels, which can lead to increased intracellular calcium levels. This calcium surge could potentially activate CRISP-2. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol is a PDE3 inhibitor leading to increased cAMP levels, which can lead to a surge in intracellular calcium potentially activating CRISP-2. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a PDE4 inhibitor that can increase cAMP levels, leading to increased intracellular calcium. The surge in calcium could activate CRISP-2. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine is a PDE1 inhibitor that leads to increased cAMP and cGMP levels, which can cause a surge in intracellular calcium. This could activate CRISP-2. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a PDE3 and PDE4 inhibitor, which can raise cAMP levels leading to increased intracellular calcium. The surge in calcium could activate CRISP-2. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone is a PDE3 inhibitor that increases cAMP levels, leading to a surge in intracellular calcium. This could potentially activate CRISP-2. | ||||||
Etazolate Hydrochloride | 35838-58-5 | sc-201186 sc-201186A | 5 mg 25 mg | $60.00 $250.00 | 5 | |
Etazolate is a PDE4 inhibitor that can raise cAMP levels, leading to increased intracellular calcium. The surge in calcium could activate CRISP-2. | ||||||