Cox-2 Inhibitors
Items 51 to 60 of 107 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
6-Methoxy-2-Naphthylacetic acid | 23981-47-7 | sc-200602 sc-200602A | 10 mg 50 mg | $84.00 $332.00 | 4 | |
6-Methoxy-2-Naphthylacetic acid demonstrates distinctive characteristics as a COX-2 inhibitor, primarily through its ability to engage in hydrogen bonding with key amino acid residues in the enzyme's active site. The presence of the methoxy group enhances electron density, facilitating interactions that stabilize the enzyme-inhibitor complex. Additionally, its naphthalene structure contributes to a unique conformational flexibility, allowing for dynamic adjustments during binding, which may influence its inhibitory potency and selectivity. | ||||||
Naproxen Sodium Salt | 26159-34-2 | sc-212361 | 25 g | $181.00 | 1 | |
Naproxen Sodium Salt exhibits unique properties as a COX-2 inhibitor, characterized by its ability to form strong pi-stacking interactions with aromatic residues in the enzyme's active site. The sodium salt form enhances solubility, promoting rapid diffusion to the target site. Its structural rigidity, derived from the naphthalene moiety, allows for precise orientation during binding, optimizing the fit within the active site and potentially influencing the kinetics of inhibition. | ||||||
Piroxicam | 36322-90-4 | sc-200576 sc-200576A | 1 g 5 g | $107.00 $369.00 | 2 | |
Piroxicam functions as a selective COX-2 inhibitor, distinguished by its unique ability to engage in hydrogen bonding with key amino acid residues in the enzyme's active site. Its extended heterocyclic structure facilitates conformational flexibility, allowing for dynamic interactions that enhance binding affinity. Additionally, the presence of a sulfonamide group contributes to its solubility profile, promoting effective molecular interactions and influencing the overall reaction kinetics within the enzymatic pathway. | ||||||
Etodolac | 41340-25-4 | sc-204747 sc-204747A | 100 mg 250 mg | $87.00 $128.00 | 1 | |
Etodolac acts as a selective COX-2 inhibitor, characterized by its unique ability to form hydrophobic interactions with the enzyme's active site. Its aromatic ring system enhances π-π stacking interactions, which stabilize the binding conformation. The presence of a carboxylic acid moiety allows for ionic interactions with charged residues, influencing the enzyme's catalytic efficiency. This multifaceted interaction profile contributes to its specificity and modulation of enzymatic activity. | ||||||
Nimesulide | 51803-78-2 | sc-200623 | 5 g | $71.00 | 1 | |
Nimesulide is a COX-2 inhibitor that reduces pain and inflammation by inhibiting the enzyme and subsequently decreasing prostaglandin levels. | ||||||
Ethyl 3,4-Dihydroxycinnamate | 66648-50-8 | sc-205930 sc-205930A | 25 mg 250 mg | $51.00 $360.00 | ||
Ethyl 3,4-Dihydroxycinnamate exhibits selective inhibition of COX-2 through its ability to engage in hydrogen bonding with key amino acid residues in the enzyme's active site. The presence of hydroxyl groups facilitates strong polar interactions, enhancing binding affinity. Additionally, its conjugated double bond system allows for resonance stabilization, influencing the kinetics of enzyme-substrate interactions. This unique interaction profile underscores its specificity in modulating COX-2 activity. | ||||||
Loxoprofen | 68767-14-6 | sc-221861 | 5 mg | $300.00 | ||
Loxoprofen demonstrates a unique mechanism of action as a selective COX-2 inhibitor, characterized by its ability to form hydrophobic interactions with the enzyme's active site. The presence of a phenyl group enhances its lipophilicity, promoting effective binding. Furthermore, the compound's structural conformation allows for steric hindrance, which selectively obstructs COX-2 while sparing COX-1. This specificity is crucial for its distinct biochemical behavior in modulating inflammatory pathways. | ||||||
Lornoxicam | 70374-39-9 | sc-207833 sc-207833A | 10 mg 100 mg | $80.00 $133.00 | ||
Lornoxicam exhibits a distinctive profile as a selective COX-2 inhibitor, primarily through its ability to engage in specific hydrogen bonding with the enzyme's active site. The presence of a thiazine ring contributes to its unique electronic distribution, facilitating targeted interactions. Additionally, its planar structure allows for optimal π-π stacking with aromatic residues, enhancing selectivity for COX-2 over COX-1 and influencing its kinetic behavior in enzymatic pathways. | ||||||
Meloxicam | 71125-38-7 | sc-200626 sc-200626A sc-200626B | 20 mg 100 mg 500 mg | $35.00 $92.00 $153.00 | 3 | |
Meloxicam inhibits COX-2, reducing pain and inflammation by blocking prostaglandin synthesis. It's commonly prescribed for osteoarthritis and other conditions. | ||||||
Ketorolac | 74103-06-3 | sc-279250 | 500 mg | $500.00 | ||
Ketorolac functions as a selective COX-2 inhibitor, characterized by its unique ability to form stable interactions with the enzyme's active site through hydrophobic and electrostatic forces. The presence of a carboxylic acid group enhances its binding affinity, while its rigid structure promotes conformational stability. This rigidity influences the reaction kinetics, allowing for a more efficient blockade of the COX-2 pathway, thereby distinguishing it from non-selective inhibitors. | ||||||