Molecular structure of 6-Methoxy-2-Naphthylacetic acid, CAS Number: 23981-47-7
6-Methoxy-2-Naphthylacetic acid (CAS 23981-47-7)
See product citations (4)
Alternate Names:
6-MNAA; 6-MNA
Application:
6-Methoxy-2-Naphthylacetic acid is a competitive and selective inhibitor of Cox-2
CAS Number:
23981-47-7
Purity:
≥99%
Molecular Weight:
216.2
Molecular Formula:
C13H12O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
6-Methoxy-2-Naphthylacetic acid is a competitive inhibitor of Cox (cyclooxygenase). 6-Methoxy-2-Naphthylacetic acid is selective for Cox-2 (IC50 = 15-55 μM) over Cox-1 (IC50 = 200-280 μM). 6-Methoxy-2-Naphthylacetic acid is a metabolite of Nabumetone with potential analgesic and anti-inflammatory effects. 6-Methoxy-2-Naphthylacetic acid has been shown to alter the pharmacokinetics and brain accumulation of IMP in monkeys. 6-Methoxy-2-Naphthylacetic acid was able to decrease reactive oxygen species creation in polymorphonuclear leukocytes. Evidence points out that 6-Methoxy-2-Naphthylacetic acid is phototoxic in vitro.
6-Methoxy-2-Naphthylacetic acid (CAS 23981-47-7) References
- Photosensitizing properties of 6-methoxy-2-naphthylacetic acid, the major metabolite of the phototoxic non-steroidal anti-inflammatory and analgesic drug nabumetone. | Canudas, N., et al. 2005. Pharmazie. 60: 604-8. PMID: 16124404
- Serum protein binding displacement: theoretical analysis using a hypothetical radiopharmaceutical and experimental analysis with 123I-N-isopropyl-p-iodoamphetamine. | Kawai, K., et al. 2009. Nucl Med Biol. 36: 99-106. PMID: 19181274
- A predominate role of CYP1A2 for the metabolism of nabumetone to the active metabolite, 6-methoxy-2-naphthylacetic acid, in human liver microsomes. | Turpeinen, M., et al. 2009. Drug Metab Dispos. 37: 1017-24. PMID: 19204080
- In vitro characterization of the cytochrome P450 isoforms involved in the metabolism of 6-methoxy-2-napthylacetic acid, an active metabolite of the prodrug nabumetone. | Matsumoto, K., et al. 2011. Biol Pharm Bull. 34: 734-9. PMID: 21532165
- Carbon-carbon bond cleavage in activation of the prodrug nabumetone. | Varfaj, F., et al. 2014. Drug Metab Dispos. 42: 828-38. PMID: 24584631
- Potential of Piperazinylalkylester Prodrugs of 6-Methoxy-2-Naphthylacetic Acid (6-MNA) for Percutaneous Drug Delivery. | Pawar, V., et al. 2015. AAPS PharmSciTech. 16: 518-27. PMID: 25370023
- A novel injection strategy of flurbiprofen axetil by inhibiting protein binding with 6-methoxy-2-naphthylacetic acid. | Ogata, K., et al. 2016. Eur J Drug Metab Pharmacokinet. 41: 179-86. PMID: 25537338
- A metabolic pathway for the prodrug nabumetone to the pharmacologically active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA) by non-cytochrome P450 enzymes. | Matsumoto, K., et al. 2020. Xenobiotica. 50: 783-792. PMID: 31855101
- Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma. | Czub, MP., et al. 2020. J Med Chem. 63: 6847-6862. PMID: 32469516
- Role of human flavin-containing monooxygenase (FMO) 5 in the metabolism of nabumetone: Baeyer-Villiger oxidation in the activation of the intermediate metabolite, 3-hydroxy nabumetone, to the active metabolite, 6-methoxy-2-naphthylacetic acid in vitro. | Matsumoto, K., et al. 2021. Xenobiotica. 51: 155-166. PMID: 33146575
- Polymorphonuclear leukocytes activation: in vitro modulation by 6-methoxy-2-naphthylacetic acid, the major active metabolite of nabumetone. | Allegrezza-Giulietti, A., et al. 1993. Pharmacol Res. 28: 163-73. PMID: 8278307
- Disposition and excretion of 6-methoxy-2-naphthylacetic acid, the active metabolite of nabumetone in horses. | Soma, LR., et al. 1996. Am J Vet Res. 57: 517-21. PMID: 8712517
- The in vitro effects of 6-methoxy-2-naphthylacetic acid, the active metabolite of nabumetone, on rat gastric mucosal eicosanoid synthesis and metabolism. | Melarange, R., et al. 1996. Prostaglandins Leukot Essent Fatty Acids. 55: 195-200. PMID: 8931119
Inhibitor of:
Cox-2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
6-Methoxy-2-Naphthylacetic acid, 10 mg | sc-200602 | 10 mg | $86.00 | |||
6-Methoxy-2-Naphthylacetic acid, 50 mg | sc-200602A | 50 mg | $339.00 |