COQ4 Activators
COQ4 Activators represent a class of chemicals that either directly or indirectly modulate the activity of COQ4, a protein crucial for the biosynthesis of coenzyme Q10 (CoQ10). CoQ10 plays an indispensable role in the electron transport chain within mitochondria. To support the myriad cellular processes that rely on efficient energy production, several compounds, like Ubiquinone and Pyrroloquinoline quinone (PQQ), serve to bolster mitochondrial biogenesis and functionality. PQQ, for instance, directly stimulates mitochondrial proliferation, which may amplify the demand for the electron transport chain constituents, thereby potentially invigorating COQ4.
Other compounds, such as α-Tocopherol and L-carnitine, interact more indirectly. While α-Tocopherol ensures the stability of CoQ10 in the mitochondrial membrane by acting as an antioxidant, L-carnitine facilitates the ingress of fatty acids into mitochondria, thus optimizing fatty acid oxidation. Enhanced oxidation subsequently escalates the demand for electron transport chain elements, which could prompt a more active role for COQ4.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Coenzyme Q10 | 303-98-0 | sc-205262 sc-205262A | 1 g 5 g | $71.00 $184.00 | 1 | |
Ubiquinone, or CoQ10, is the product of the pathway in which COQ4 is involved. Increased levels can induce feedback mechanisms that enhance the activity or expression of enzymes in its synthesis pathway, potentially including COQ4. | ||||||
Pyrroloquinoline quinone | 72909-34-3 | sc-210178 | 1 mg | $243.00 | ||
PQQ is known to stimulate mitochondrial biogenesis. Increased mitochondrial numbers may lead to increased demand for components of the electron transport chain, potentially upregulating COQ4. | ||||||
(+)-α-Tocopherol | 59-02-9 | sc-214454 sc-214454A sc-214454B sc-214454C | 10 g 25 g 100 g 1 kg | $43.00 $62.00 $141.00 | ||
As an antioxidant, it can protect CoQ10 in the mitochondrial membrane. This protection may influence the homeostasis of CoQ10, potentially influencing COQ4 activity. | ||||||
L-Carnitine | 541-15-1 | sc-205727 sc-205727A sc-205727B sc-205727C | 1 g 5 g 100 g 250 g | $23.00 $34.00 $79.00 $179.00 | 3 | |
L-carnitine aids in fatty acid transport into mitochondria. Enhanced fatty acid oxidation can increase the demand for electron transport chain components, potentially activating COQ4. | ||||||
NAD+, Free Acid | 53-84-9 | sc-208084B sc-208084 sc-208084A sc-208084C sc-208084D sc-208084E sc-208084F | 1 g 5 g 10 g 25 g 100 g 1 kg 5 kg | $57.00 $191.00 $302.00 $450.00 $1800.00 $3570.00 $10710.00 | 4 | |
NADH is a direct participant in the electron transport chain. An increase in NADH may augment the demand for CoQ10, potentially activating COQ4. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR stimulates AMPK, which can promote mitochondrial biogenesis. This may lead to increased demand for COQ4's role in CoQ10 synthesis. | ||||||
SRT1720 | 1001645-58-4 | sc-364624 sc-364624A | 5 mg 10 mg | $197.00 $364.00 | 13 | |
Activation of sirtuins can lead to increased mitochondrial function and biogenesis, potentially enhancing COQ4 activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Known to stimulate Nrf2, which can enhance mitochondrial function and antioxidative pathways. This could influence COQ4's role in CoQ10 synthesis. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $69.00 $122.00 $212.00 $380.00 $716.00 | 3 | |
Influences mitochondrial function and can increase the demand for CoQ10, possibly activating COQ4. | ||||||
Methylene blue | 61-73-4 | sc-215381B sc-215381 sc-215381A | 25 g 100 g 500 g | $43.00 $104.00 $328.00 | 3 | |
By accepting electrons and supporting the electron transport chain, it might enhance the demand for components synthesized by COQ4. | ||||||