COL6A2 Activators
The collagen VI alpha 2 chain, commonly referred to by its gene symbol COL6A2, is one of the three major alpha chains constituting the collagen VI microfibrillar network, the others being COL6A1 and COL6A3. Collagen VI is an extracellular matrix (ECM) protein, and it plays pivotal roles in cell adhesion, cell migration, and the structural integrity of various tissues. The synthesis, assembly, and secretion of collagen VI into the ECM are intricate processes that are meticulously regulated at the transcriptional and post-translational levels. COL6A2 activators, as the name suggests, are chemical entities that can augment the expression or activity of COL6A2.
The intricate nature of collagen VI synthesis involves a series of molecular events, where alpha chains form heterotrimers in the endoplasmic reticulum, followed by the assembly of these trimers into tetramers in the ECM. The role of COL6A2 activators is to modulate these processes either directly by enhancing the synthesis and secretion of the COL6A2 chain or indirectly by influencing associated molecular pathways that impact COL6A2 expression. Several mechanisms can underlie the action of these activators, ranging from transcriptional upregulation of the COL6A2 gene to the stabilization of the protein product post-translationally. Understanding the mechanisms and factors that influence COL6A2 levels can shed light on the broader landscape of collagen VI biology and its implications in tissue homeostasis and structural resilience.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is crucial for the hydroxylation of proline residues in collagen, enhancing collagen's structural stability. This process indirectly activates COL6A2 functionality by ensuring proper collagen folding and assembly, essential for the formation of stable and functional collagen VI fibers. | ||||||
Copper(II) sulfate | 7758-98-7 | sc-211133 sc-211133A sc-211133B | 100 g 500 g 1 kg | $46.00 $122.00 $189.00 | 3 | |
Copper ions are cofactors for lysyl oxidase, an enzyme that cross-links collagen fibers. By supporting cross-linking, copper sulfate indirectly activates COL6A2 by promoting the assembly and stabilization of type VI collagen fibers, crucial for extracellular matrix integrity. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese is a cofactor for prolidase, an enzyme involved in collagen synthesis by recycling proline. This indirectly activates COL6A2 by supporting the synthesis and assembly of collagen fibers, ensuring the structural integrity of the extracellular matrix. | ||||||
α-Ketoglutaric Acid | 328-50-7 | sc-208504 sc-208504A sc-208504B sc-208504C sc-208504D sc-208504E sc-208504F | 25 g 100 g 250 g 500 g 1 kg 5 kg 16 kg | $33.00 $43.00 $63.00 $110.00 $188.00 $738.00 $2091.00 | 2 | |
α-Ketoglutarate is a co-substrate for prolyl-4-hydroxylase, necessary for collagen maturation. It indirectly activates COL6A2 by facilitating the hydroxylation of proline, critical for the stability and assembly of type VI collagen fibers. | ||||||
Succinic acid | 110-15-6 | sc-212961B sc-212961 sc-212961A | 25 g 500 g 1 kg | $45.00 $75.00 $133.00 | ||
Succinic acid is involved in the citric acid cycle and indirectly supports energy production necessary for collagen synthesis. By sustaining cellular metabolism, it indirectly activates COL6A2 through the enhanced synthesis and assembly of collagen fibers. | ||||||
Glycine | 56-40-6 | sc-29096A sc-29096 sc-29096B sc-29096C | 500 g 1 kg 3 kg 10 kg | $41.00 $71.00 $112.00 $357.00 | 15 | |
Glycine is a major constituent of collagen. By providing the necessary amino acid, it indirectly activates COL6A2 by contributing to the primary structure and stability of collagen fibers, essential for proper function and extracellular matrix formation. | ||||||
L-Proline | 147-85-3 | sc-397196 sc-397196A sc-397196B sc-397196C | 25 g 100 g 1 kg 5 kg | $38.00 $133.00 $208.00 $978.00 | ||
Proline is critical for collagen helix formation. Its availability indirectly activates COL6A2 by ensuring the proper helical structure of collagen, essential for the strength and integrity of collagen fibers. | ||||||
L-Lysine | 56-87-1 | sc-207804 sc-207804A sc-207804B | 25 g 100 g 1 kg | $95.00 $263.00 $529.00 | ||
Lysine is necessary for the cross-linking of collagen fibers. By serving as a substrate for lysyl oxidase, it indirectly activates COL6A2 by facilitating the formation of stable, cross-linked collagen networks. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc is a cofactor for collagenase, which remodels collagen fibers. By indirectly supporting the turnover and restructuring of collagen, zinc sulfate activates COL6A2 functionality, ensuring the dynamic balance of collagen synthesis and degradation. | ||||||
Colloidal silica, 30% susp. in H2O | 7631-86-9 | sc-252972 sc-252972A | 1 L 4 L | $62.00 $135.00 | ||
Silicon is involved in collagen synthesis and bone mineralization. It indirectly activates COL6A2 by supporting the synthesis and stabilization of collagen fibers, contributing to the integrity of the extracellular matrix. | ||||||