COH1 Activators
COH1, also known as VPS13B, plays a critical role in cellular function, with its involvement in the intracellular transport of proteins and the maintenance of the Golgi apparatus' structural integrity. The proper expression of COH1 is crucial for diverse cellular processes, including vesicle-mediated transport and maintaining the equilibrium of the cellular membrane's composition. The gene encoding COH1, VPS13B, is highly conserved among different species, highlighting its importance in cellular homeostasis. Disruptions in the normal expression of COH1 can have significant cellular consequences, given the protein's expansive role in cell biology.
The regulation of COH1 expression is a complex process that can be influenced by various chemical activators, which can stimulate gene expression through different mechanisms. For example, compounds like retinoic acid might enhance COH1 expression through the activation of retinoic acid receptors, which in turn may bind to specific promoter regions of the gene, initiating transcription. Similarly, epigenetic modifiers such as 5-Azacytidine could lead to the upregulation of COH1 by causing the demethylation of the gene's promoter region, thus stimulating transcription. Other compounds like Trichostatin A could increase COH1 expression by promoting histone acetylation, leading to a more transcriptionally active chromatin state around the COH1 gene. Moreover, signaling molecules like Forskolin, which raise intracellular cAMP levels, might also contribute to the enhanced expression of COH1 by activating downstream protein kinases that phosphorylate and activate transcription factors. Collectively, these compounds represent a spectrum of molecules that, through their interaction with cellular pathways, have the potential to increase the expression of COH1, thereby influencing cellular functionality and homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid may upregulate COH1 by interacting with retinoic acid receptors, which could initiate transcriptional activation of COH1 through the binding to response elements in its promoter region. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methylation, 5-Azacytidine could lead to the demethylation of the COH1 promoter, potentially removing epigenetic silencing and stimulating the transcription of the COH1 gene. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A may increase COH1 expression by promoting histone acetylation, thereby creating an accessible chromatin configuration around the COH1 gene locus and facilitating transcriptional machinery access. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin may stimulate COH1 expression through cAMP elevation, subsequently activating protein kinase A (PKA), which could then enhance the phosphorylation of transcription factors targeting the COH1 gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol could upregulate COH1 indirectly by activating sirtuins and influencing the FOXO transcription factors, which in turn may promote transcriptional activation of genes including COH1. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 18 | |
Sodium butyrate may increase the transcription of COH1 by inhibiting histone deacetylases, which leads to an open chromatin state and potentially facilitates the recruitment of transcriptional machinery to the COH1 locus. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol could stimulate COH1 transcription via estrogen receptor-mediated activation, which may involve the binding of estrogen-receptor complexes to estrogen response elements near the COH1 gene. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride might promote upregulation of COH1 by inhibiting GSK-3, leading to the stabilization and activation of transcription factors that could enhance COH1 gene transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
As a polyphenol, epigallocatechin gallate may stimulate COH1 expression by altering DNA methylation patterns and histone acetylation statuses, thereby creating a chromatin environment conducive to gene transcription. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane might stimulate the expression of COH1 by activating the NRF2 pathway, which could lead to the binding of NRF2 to antioxidant response elements in the promoter regions of various genes, including possibly COH1. | ||||||