CNG-3 Activators
CNG-3 Activators comprise a diverse array of chemical compounds that primarily modulate intracellular levels of cyclic nucleotides, thus indirectly influencing the activity of CNG-3, a cyclic nucleotide-gated channel. Forskolin, for instance, directly increases the cellular concentration of cAMP, which is a natural ligand for CNG-3, leading to the channel's activation and increased ion conductance. Similarly, IBMX and Theophylline act as non-selective phosphodiesterase inhibitors, raising both cAMP and cGMP levels, thereby facilitating the activation of CNG-3. On the other hand, Vinpocetine and Zaprinast, by specifically inhibiting PDE1 and PDE5 respectively, cause an elevation in cGMP concentrations, a key factor in CNG-3 activation, highlighting the nuanced regulation of CNG-3 by different cyclic nucleotide pathways.
Further specificity in CNG-3 activation is seen with compounds like Sildenafil and Cilostazol, which, through the inhibition of PDE5 and PDE3, augment cGMP and cAMP levels respectively, tailoring the activation profile of CNG-3. Dipyridamole's broad inhibition of phosphodiesterases also contributes to the increased availability of cAMP and cGMP, thereby promoting CNG-3 activity. Rolipram, with its PDE4 selectivity, and Milrinone and Anagrelide, which are selective for PDE3, preferentially increase cAMP levels.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly elevates intracellular cAMP levels, which can lead to the activation of CNG-3 by promoting the opening of cyclic nucleotide-gated channels, thus enhancing ion flow across cell membranes. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX acts as a non-selective inhibitor of phosphodiesterases, leading to increased cAMP levels in the cell, which indirectly enhances the activity of CNG-3 by preventing cAMP breakdown. | ||||||
Vinpocetine | 42971-09-5 | sc-201204 sc-201204A sc-201204B | 20 mg 100 mg 15 g | $55.00 $214.00 $2400.00 | 4 | |
Vinpocetine inhibits phosphodiesterase type 1 (PDE1), which increases cAMP and cGMP levels in neuronal cells, potentially leading to the activation of CNG-3 channels. | ||||||
Zaprinast (M&B 22948) | 37762-06-4 | sc-201206 sc-201206A | 25 mg 100 mg | $103.00 $245.00 | 8 | |
Zaprinast selectively inhibits PDE5, which increases cGMP levels and can activate CNG-3 by increasing the ligand available for binding and channel opening. | ||||||
Cilostazol | 73963-72-1 | sc-201182 sc-201182A | 10 mg 50 mg | $107.00 $316.00 | 3 | |
Cilostazol inhibits PDE3, which leads to increased cAMP levels, thereby indirectly activating CNG-3 through cAMP-dependent protein kinase signaling pathways. | ||||||
Dipyridamole | 58-32-2 | sc-200717 sc-200717A | 1 g 5 g | $30.00 $100.00 | 1 | |
Dipyridamole inhibits various phosphodiesterases, thereby increasing cAMP and cGMP levels, which can enhance the activation of CNG-3 channels indirectly. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $31.00 $83.00 | 6 | |
Theophylline is a non-selective phosphodiesterase inhibitor, which indirectly activates CNG-3 by increasing intracellular levels of cAMP and cGMP, the ligands necessary for CNG-3 channel activation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram selectively inhibits PDE4 and raises intracellular cAMP levels, which could enhance the activation of CNG-3 by promoting cAMP-mediated signaling. | ||||||
Milrinone | 78415-72-2 | sc-201193 sc-201193A | 10 mg 50 mg | $162.00 $683.00 | 7 | |
Milrinone selectively inhibits PDE3, leading to raised cAMP levels and subsequent activation of CNG-3 through cAMP-dependent pathways. | ||||||
Anagrelide | 68475-42-3 | sc-491875 | 25 mg | $147.00 | ||
Anagrelide inhibits PDE3, increasing cAMP levels, which could lead to the enhanced activity of CNG-3 by stimulating cAMP-dependent signaling mechanisms. | ||||||