CMBL Activators

CMBL, or Carboxymethylenebutenolidase homolog, is an enzyme encoded by the CMBL gene in humans. It is classified as a cysteine hydrolase and is involved in the metabolic processing of various compounds within the body. CMBL is particularly noted for its role in drug metabolism, where it functions in the bioactivation of certain prodrugs-inactive compounds that are metabolized into an active pharmacological agent. An example of its role in drug metabolism is the conversion of the prodrug olmesartan medoxomil into its active form, olmesartan, used in high blood pressure.

The enzyme is part of the broader system of xenobiotic metabolism, which encompasses the transformation and clearance of foreign substances from the body. This system is crucial for detoxifying drugs, pollutants, and other environmental chemicals, thereby protecting the body from toxic effects.CMBL's activity is not limited to drug metabolism; it also participates in general cellular processes, including the regulation of endogenous compounds that may have signaling roles or be involved in cellular homeostasis. The expression of the CMBL gene and the activity of the enzyme can be influenced by various factors, including dietary components, environmental toxins, and physiological stressors.