CMBL Activators
CMBL, or Carboxymethylenebutenolidase homolog, is an enzyme encoded by the CMBL gene in humans. It is classified as a cysteine hydrolase and is involved in the metabolic processing of various compounds within the body. CMBL is particularly noted for its role in drug metabolism, where it functions in the bioactivation of certain prodrugs-inactive compounds that are metabolized into an active pharmacological agent. An example of its role in drug metabolism is the conversion of the prodrug olmesartan medoxomil into its active form, olmesartan, used in high blood pressure.
The enzyme is part of the broader system of xenobiotic metabolism, which encompasses the transformation and clearance of foreign substances from the body. This system is crucial for detoxifying drugs, pollutants, and other environmental chemicals, thereby protecting the body from toxic effects.CMBL's activity is not limited to drug metabolism; it also participates in general cellular processes, including the regulation of endogenous compounds that may have signaling roles or be involved in cellular homeostasis. The expression of the CMBL gene and the activity of the enzyme can be influenced by various factors, including dietary components, environmental toxins, and physiological stressors.
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
May activate Nrf2, a transcription factor that regulates the expression of detoxifying enzymes, potentially affecting CMBL. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
Known to induce phase II detoxification enzymes through Nrf2 signaling, which may upregulate CMBL expression. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Found in cruciferous vegetables, it can modulate various detoxification enzymes, possibly influencing CMBL expression. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Acts on sirtuins and other signaling pathways, which could lead to changes in the expression of genes like CMBL. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that affects signaling pathways and gene expression, potentially impacting CMBL levels. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
The active component of green tea, known to influence multiple gene expression pathways, possibly including CMBL. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A phytoestrogen that can modulate gene expression, potentially affecting CMBL. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
A compound found in indole-3-carbinol digestion, known to influence detoxification enzyme gene expression. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $58.00 $95.00 $245.00 $727.00 | 8 | |
A polyphenol that may modulate gene expression related to oxidative stress and detoxification, potentially affecting CMBL. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $71.00 $296.00 $612.00 | 19 | |
A component of propolis with potential regulatory effects on gene expression, which may include CMBL. | ||||||