Choriogonadotropin β Activators

Choriogonadotropin β (hCG beta) activators encompass a diverse range of chemicals that indirectly influence the production, release, or activity of this hormone. This class includes selective estrogen receptor modulators (SERMs) like Clomiphene Citrate and Tamoxifen, which increase gonadotropin levels by blocking estrogen receptors. This blockade leads to a negative feedback reduction on the hypothalamus and pituitary, consequently elevating gonadotropin-releasing hormone (GnRH) and stimulating the production of hCG. Additionally, aromatase inhibitors such as Letrozole enhance gonadotropin release by inhibiting estrogen synthesis, thereby indirectly boosting hCG levels.

The category also includes compounds that act on the hypothalamic-pituitary-gonadal axis, such as GnRH agonists and antagonists (e.g., Cetrorelix, Ganirelix, Leuprolide Acetate). These substances modulate the release of gonadotropins, which in turn influences hCG secretion. Dopamine and dopamine agonists like Cabergoline also play a role, as they can reduce prolactin levels, which might affect gonadotropin release. Forskolin, a plant-derived compound, activates adenylate cyclase, potentially enhancing the synthesis and secretion of hCG. The inclusion of Follistatin, known for its role in binding and inhibiting activin, suggests a more indirect but significant potential impact on hCG levels, as activin modulates the secretion of several hormones including gonadotropins. Lastly, compounds like Ketoconazole, which inhibit steroid synthesis, might indirectly affect hCG levels due to the complex interplay of hormones within the reproductive system.