CENP-VL1 Inhibitors
CENP-VL1 inhibitors encompass a variety of chemical compounds that function through diverse mechanisms to impede the activity of this centromere-associated protein. Inhibition of cyclin-dependent kinases results in cell cycle arrest, preventing CENP-VL1 from effectively participating in cell division. Additionally, the use of compounds that modify chromatin structure through increased histone acetylation or reduced DNA methylation can lead to alterations in the chromosomal binding and function of CENP-VL1. These chromatin-modifying agents cause structural changes that can inhibit the proper association of CENP-VL1 with centromeric DNA, thus compromising its essential role in chromosome segregation during mitosis.
Furthermore, targeting specific kinases involved in the DNA damage response or mitotic spindle formation disrupts processes critical for the recruitment and function of CENP-VL1 at the centromere. Chemicals that induce DNA crosslinking or interfere with microtubule dynamics exert indirect effects on the centromere and associated proteins, including CENP-VL1. By destabilizing microtubule dynamics or inducing DNA damage, these compounds can interfere with the localization and function of CENP-VL1, which is crucial for maintaining genomic stability during cell division. Proteasome inhibitors and agents that reduce nucleotide pools also contribute to the indirect inhibition of CENP-VL1 by causing the accumulation of misfolded proteins or by impeding DNA replication, respectively, further substantiating the diverse array of mechanisms employed by CENP-VL1 inhibitors.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $315.00 | ||
A cyclin-dependent kinase inhibitor that specifically inhibits CDK4/6, leading to cell cycle arrest at the G1 phase. This would prevent CENP-VL1 from being recruited to the centromere during cell division due to halted cell cycle progression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
A histone deacetylase inhibitor that increases acetylation of histones, thereby altering chromatin structure and affecting the function of proteins such as CENP-VL1 that are associated with chromatin. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that reduces DNA methylation. Hypomethylation of DNA could affect the binding of CENP-VL1 to chromatin, as DNA methylation status is known to influence protein-DNA interactions. | ||||||
VE 821 | 1232410-49-9 | sc-475878 | 10 mg | $360.00 | ||
An inhibitor of ATR kinase, crucial for DNA damage response. By inhibiting ATR, the recruitment and function of CENP-VL1 at the centromere during DNA damage response could be impacted. | ||||||
MLN8237 | 1028486-01-2 | sc-394162 | 5 mg | $220.00 | ||
An Aurora kinase A inhibitor which disrupts mitotic spindle formation and could indirectly affect CENP-VL1's role in chromosomal segregation during mitosis. | ||||||
Mitomycin C | 50-07-7 | sc-3514A sc-3514 sc-3514B | 2 mg 5 mg 10 mg | $65.00 $99.00 $140.00 | 85 | |
An alkylating agent that crosslinks DNA strands. This can lead to a defective chromosomal structure, potentially impacting the function of centromere-associated proteins like CENP-VL1. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule-depolymerizing agent that disrupts the mitotic spindle and could interfere with the proper localization and function of CENP-VL1 during mitosis. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
A microtubule-stabilizing agent that, by freezing microtubule dynamics, can disrupt the functions of proteins involved in chromosome movement and segregation, potentially affecting CENP-VL1. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that can lead to the accumulation of misfolded proteins, which may include CENP-VL1, thus potentially interfering with its proper function. | ||||||
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $76.00 $255.00 | 18 | |
An inhibitor of ribonucleotide reductase that leads to decreased DNA synthesis. This could indirectly affect the function of CENP-VL1 during DNA replication and cell division. | ||||||