CED-9 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is a benzophenanthridine alkaloid that can act as a protein kinase C inhibitor, which might affect signal transduction pathways and could indirectly influence the expression of apoptotic regulators homologous to CED-9. | ||||||
Sanguinarium | 2447-54-3 | sc-473396 | 10 mg | $220.00 | ||
Sanguinarium, another benzophenanthridine alkaloid, could inhibit NF-κB activation, which may be involved in the transcriptional regulation of apoptosis-related genes and thereby might affect CED-9 expression. | ||||||
Obatoclax | 803712-67-6 | sc-507476 | 10 mg | $348.00 | ||
Obatoclax is a small-molecule pan-Bcl-2 antagonist that could theoretically inhibit proteins similar to CED-9 by binding to the hydrophobic groove on Bcl-2 family proteins, potentially influencing their expression. | ||||||
ABT 737 | 852808-04-9 | sc-207242 | 2.5 mg | $204.00 | 54 | |
ABT 737 is a Bcl-2 family protein antagonist that could mimic the inhibition of Bcl-2-like proteins and might affect the expression of CED-9 homologs by modulating the intrinsic apoptotic pathway. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $116.00 $230.00 | 12 | |
Gossypol is a natural compound that acts as a Bcl-2 inhibitor, which could influence pathways similar to those regulated by CED-9 in C. elegans by binding to the BH3 domain on Bcl-2 family proteins. | ||||||
TW-37 | 877877-35-5 | sc-361387 sc-361387A | 10 mg 50 mg | $200.00 $860.00 | 2 | |
TW-37 is designed to bind to the BH3 binding groove of Bcl-2 proteins, potentially influencing similar regulatory proteins in C. elegans and could hypothetically affect CED-9 expression. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases the levels of reactive oxygen species, which can affect signaling pathways and potentially reduce the expression of apoptosis-regulating proteins such as CED-9. | ||||||
Phenethyl isothiocyanate | 2257-09-2 | sc-205801 sc-205801A | 5 g 10 g | $104.00 $183.00 | 2 | |
This compound modifies proteins through alkylation and can disrupt multiple cellular processes, potentially including those regulating the expression of proteins like CED-9. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide affects various signaling pathways and has been shown to downregulate Bcl-2 family proteins, which suggests it could have a similar effect on CED-9 expression. | ||||||