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Cdk11 Inhibitors

Cdk11, also known as Cyclin-dependent kinase 11, is a multifaceted protein integral to various cellular processes, including RNA transcription, cell cycle progression, and apoptotic signaling. It is encoded by a complex gene that produces multiple transcript variants, each giving rise to distinct isoforms of the protein. Cdk11's activity is tightly regulated through its association with cyclins and other regulatory proteins, ensuring proper timing and fidelity of cellular division and growth. Abnormalities in Cdk11 expression or function have been linked to a host of cellular dysfunctions, underscoring its critical role in maintaining cellular homeostasis. Given its pivotal position in cellular regulation, Cdk11 has become a subject of interest for researchers studying the molecular underpinnings of cell cycle control and its associated pathways. In the quest to understand how to modulate Cdk11 activity, a variety of chemical compounds have been identified that could potentially inhibit its expression. These inhibitors are a diverse group of molecules that may interact with Cdk11 or its associated pathways at different levels. For instance, some compounds might directly inhibit the kinase activity of Cdk11 by competing with ATP for binding to the kinase domain. Other inhibitors might interfere with the transcriptional regulation of the CDK11 gene, potentially leading to a decrease in mRNA synthesis and thus a reduction in protein levels. Yet another group of compounds may indirectly downregulate Cdk11 expression by destabilizing regulatory proteins or altering signaling pathways that are upstream of CDK11. The potential inhibitors range from naturally occurring substances, like flavonoids, which may alter kinase function, to synthetic molecules designed to target specific domains within the protein. It's important to note that while these chemicals have been identified as potential inhibitors of Cdk11 expression, their exact mechanisms of action and the specificity of their interactions with Cdk11 or its regulatory pathways require further elucidation through rigorous scientific experimentation.

Items 1 to 10 of 11 total

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Product Name	CAS #	Catalog #	QUANTITY	Price	Citations	RATING
Flavopiridol	146426-40-6	sc-202157 sc-202157A	5 mg 25 mg	$78.00 $259.00	41	(3)
Flavopiridol acts as a selective inhibitor of cyclin-dependent kinase 11 (Cdk11), exhibiting a unique mechanism of action by disrupting the enzyme's catalytic cycle. Its binding affinity to the ATP-binding pocket induces conformational changes that prevent substrate phosphorylation. This alteration in enzyme dynamics can lead to a cascade of effects on transcriptional regulation and cell cycle progression, highlighting its intricate role in cellular signaling networks.
Roscovitine	186692-46-6	sc-24002 sc-24002A	1 mg 5 mg	$94.00 $265.00	42	(2)
As a selective inhibitor of Cdk2, Cdk7, and Cdk9, Roscovitine might exhibit cross-inhibition to Cdk11, potentially leading to a reduction in Cdk11's phosphorylation activity and a subsequent decrease in its expression levels.
Olomoucine	101622-51-9	sc-3509 sc-3509A	5 mg 25 mg	$72.00 $274.00	12	(1)
Olomoucine competes with ATP for binding to the active site of several CDKs, which may include Cdk11, potentially inhibiting its kinase function and reducing its protein levels through decreased transcription or increased degradation.
Indirubin	479-41-4	sc-201531 sc-201531A	5 mg 25 mg	$114.00 $525.00	4	(1)
Indirubin is a broad-spectrum CDK inhibitor that may non-specifically target Cdk11, leading to inhibited kinase activity and decreased expression through disrupted cell cycle checkpoints.
Curcumin	458-37-7	sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E	1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg	$37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00	47	(1)
Curcumin has been shown to inhibit the transcriptional activity of AP-1, which could downregulate the expression of Cdk11 if AP-1 is involved in its gene regulation.
Trichostatin A	58880-19-6	sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D	1 mg 5 mg 10 mg 25 mg 50 mg	$152.00 $479.00 $632.00 $1223.00 $2132.00	33	(3)
Trichostatin A, by inhibiting histone deacetylase, may lead to hyperacetylation of histones near the CDK11 gene, potentially resulting in transcriptional repression and lower Cdk11 expression.
Suberoylanilide Hydroxamic Acid	149647-78-9	sc-220139 sc-220139A	100 mg 500 mg	$133.00 $275.00	37	(2)
Suberoylanilide Hydroxamic Acid (Vorinostat) can lead to altered histone modification patterns; this may cause the repression of CDK11 gene transcription and a corresponding decrease in Cdk11 protein levels.
5-Azacytidine	320-67-2	sc-221003	500 mg	$280.00	4	(1)
By inhibiting DNA methyltransferase, 5-Azacytidine may cause hypomethylation of the CDK11 gene promoter, potentially leading to reduced transcription and lower levels of Cdk11.
Rapamycin	53123-88-9	sc-3504 sc-3504A sc-3504B	1 mg 5 mg 25 mg	$63.00 $158.00 $326.00	233	(4)
Rapamycin inhibits mTOR signaling, which could lead to a reduction in cap-dependent translation, potentially decreasing the synthesis of proteins including Cdk11.
Nutlin-3	548472-68-0	sc-45061 sc-45061A sc-45061B	1 mg 5 mg 25 mg	$62.00 $225.00 $779.00	24	(1)
Nutlin-3 disrupts p53-MDM2 binding, leading to the stabilization of p53; this could result in a transcriptional response that includes the downregulation of Cdk11 if it is p53-responsive.

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Cdk11 Inhibitors

Flavopiridol

Roscovitine

Olomoucine

Indirubin

Curcumin

Trichostatin A

Suberoylanilide Hydroxamic Acid

5-Azacytidine

Rapamycin

Nutlin-3