Cdc42EP4 Activators
Cdc42EP4 activators are chemical compounds that enhance the functional activity of Cdc42EP4, a protein involved in cell morphogenesis and actin cytoskeleton organization. These activators work by influencing specific cellular processes and signaling pathways that Cdc42EP4 is directly involved in. Compounds such as EHT1864, Y-27632 and Fasudil enhance Cdc42EP4 activity by inhibiting other members of the Rho family of GTPases, such as Rac1 and ROCK. This inhibition leads to an increase in the relative activity of Cdc42, the protein that Cdc42EP4 directly interacts with, thereby indirectly enhancing the activity of Cdc42EP4.
Additionally, several Cdc42EP4 activators function by modulating the activity of Cdc42 and its downstream effectors. Wiskostatin, CK-666, CK-869, IPA-3 and FRAX597 inhibit the downstream effectors of Cdc42, including the N-WASP-Arp2/3 complex and PAK1. Inhibition of these effectors increases the availability of Cdc42, which in turn can enhanceCdc42EP4 activity.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT1864 is an inhibitor of Rac1, a member of the Rho family of GTPases. By inhibiting Rac1, EHT1864 can indirectly enhance Cdc42EP4 activity by increasing the propensity of Cdc42 to bind with Cdc42EP4. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of ROCK, a downstream effector of RhoA. Inhibition of ROCK can increase the relative activity of Cdc42, indirectly enhancing Cdc42EP4 activity. | ||||||
Fasudil, Monohydrochloride Salt | 105628-07-7 | sc-203418 sc-203418A sc-203418B sc-203418C sc-203418D sc-203418E sc-203418F | 10 mg 50 mg 250 mg 1 g 2 g 5 g 10 g | $18.00 $33.00 $87.00 $168.00 $253.00 $496.00 $910.00 | 5 | |
Fasudil is a potent inhibitor of ROCK, a downstream effector of RhoA. Inhibition of ROCK can increase the relative activity of Cdc42, indirectly enhancing Cdc42EP4 activity. | ||||||
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
Wiskostatin is an inhibitor of the N-WASP-Arp2/3 complex, a downstream effector of Cdc42. Inhibition of this complex can indirectly enhance Cdc42EP4 activity by increasing the availability of Cdc42. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
CK-666 is an inhibitor of the Arp2/3 complex, a downstream effector of Cdc42. Inhibition of this complex can indirectly enhance Cdc42EP4 activity by increasing the availability of Cdc42. | ||||||
CK-869 | 388592-44-7 | sc-507274 | 5 mg | $163.00 | ||
CK-869 is an inhibitor of the Arp2/3 complex, a downstream effector of Cdc42. Inhibition of this complex can indirectly enhance Cdc42EP4 activity by increasing the availability of Cdc42. | ||||||
IPA 3 | 42521-82-4 | sc-204016 sc-204016A | 5 mg 50 mg | $94.00 $458.00 | 6 | |
IPA-3 is a selective inhibitor of the PAK1, a downstream effector of Cdc42. Inhibition of PAK1 can indirectly enhance Cdc42EP4 activity by increasing the availability of Cdc42. | ||||||