Cdc27 Inhibitors

Cdc27 inhibitors represent a class of chemical compounds designed to target and disrupt the activity of the Cdc27 protein within the cell cycle regulatory machinery. Cdc27, also known as ANAPC3 (Anaphase Promoting Complex Subunit 3), is a crucial component of the Anaphase-Promoting Complex/Cyclosome (APC/C), which plays a pivotal role in regulating the progression of the eukaryotic cell cycle. The cell cycle is a highly orchestrated process that ensures the accurate duplication and segregation of genetic material during cell division.

To maintain this precision, the APC/C, with Cdc27 as one of its core subunits, regulates the degradation of specific proteins at key checkpoints, allowing the cell cycle to progress in a controlled manner. Cdc27 inhibitors are designed to interfere with the function of Cdc27, disrupting the proper functioning of the APC/C and, consequently, the cell cycle progression. By inhibiting Cdc27, these compounds can perturb the normal degradation of cell cycle regulators, leading to cell cycle arrest or dysregulation.