Cdc10 Inhibitors

Cdc10, a key regulator of cell cycle progression, is essential for coordinating various cellular processes such as DNA replication, chromosome segregation, and cytokinesis. As a member of the cell division cycle (CDC) family of proteins, Cdc10 functions as a component of the septation initiation network (SIN) pathway in yeast, where it regulates the onset of cytokinesis and septum formation. Cdc10 acts as a scaffold protein that facilitates the assembly of the SIN signaling complex, promoting the activation of downstream effectors involved in cytokinesis. Additionally, Cdc10 is subject to strict regulatory control during the cell cycle, with its activity and abundance tightly regulated by post-translational modifications and proteolytic degradation mechanisms.

Inhibition of Cdc10 encompasses various strategies aimed at downregulating its activity and disrupting its function in cell cycle progression. Direct inhibitors of Cdc10 target key regulatory mechanisms involved in its activation, including phosphorylation by cyclin-dependent kinases (CDKs) and casein kinase 1 (CK1), as well as ubiquitination-mediated degradation by the anaphase-promoting complex/cyclosome (APC/C). Additionally, inhibitors of upstream regulators such as Polo-like kinase 1 (Plk1) and activators of APC/C offer alternative approaches to modulating Cdc10 function. By interfering with the molecular pathways and protein-protein interactions essential for Cdc10 activity, these inhibitors provide valuable tools for investigating the role of Cdc10 in cell cycle regulation.