CD3 Activators
Common CD3 Activators include, but are not limited to R-848 CAS 144875-48-9, PMA CAS 16561-29-8, Valproic acid sodium salt CAS 1069-66-5, 5-Aza-2′-Deoxycytidine CAS 2353-33-5 and Cyclosporin A CAS 59865-13-3.
CD3 Activators is a chemical class of compounds that interact with CD3 molecules on the surface of T cells, playing a crucial role in T cell activation and immune responses. CD3 is an integral component of the T cell receptor (TCR) complex, responsible for transmitting signals from the TCR to the interior of the T cell upon antigen recognition. CD3 Activators are designed to stimulate T cell responses by mimicking the interaction between TCRs and antigens. When these activators bind to CD3 molecules, they trigger a cascade of intracellular signaling events that lead to T cell activation, proliferation, and cytokine production.
CD3 Activators have applications in immunology research and development. By manipulating CD3 activation, scientists can gain insights into the complex signaling pathways that regulate T cell responses to antigens. This understanding could pave the way for innovative immunotherapies that modulate T cell activation, either enhancing immune responses to combat infections and cancer or dampening excessive immune reactions in autoimmune diseases. The field of CD3 activation is dynamic, with ongoing research aiming to uncover new ways to harness T cell responses for various research applications.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
Resiquimod stimulates TLR7 and TLR8, which are pattern recognition receptors expressed on immune cells. TLR activation triggers signaling pathways that lead to the production of cytokines and chemokines, promoting immune responses. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates PKC, which is involved in multiple signaling pathways, including T cell activation. Ionomycin raises intracellular calcium levels. Together, PMA and ionomycin can induce strong T cell activation signals. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $87.00 | 9 | |
Valproic acid is a well-known HDAC inhibitor that affects gene expression by increasing histone acetylation. This leads to a more open chromatin structure, facilitating the binding of transcription factors to gene promoters. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
Decitabine is a nucleoside analog that incorporates into DNA during replication and forms covalent bonds with DNA methyltransferases (DNMTs). This leads to DNMT inhibition and subsequent DNA hypomethylation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $96.00 $264.00 | 2 | |
Ionomycin raises intracellular calcium levels. PMA activates PKC, which is involved in multiple signaling pathways, including T cell activation. | ||||||